Lee Chee Khoon, Yang Xue, Goto Yasushi, Lee Kang Yun, Yim Hyung Seok, Brooke Mark, Aoshima Hisakazu, Ando Emiko, Liu Yiting, Tsai Jane, Low Grace Kah Mun, Kishiwada Naomi, Cheng Simone Marie, Rajendran Divashini, Gowindah Regina, Mon Soe Pwint Phoo, Hong Min Hee
Cancer Care Centre, St George Hospital, Kogarah, New South Wales, Australia.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Cancer, Peking University Cancer Hospital & Institute, Beijing, China.
Future Oncol. 2025 Sep;21(22):2851-2865. doi: 10.1080/14796694.2025.2499511. Epub 2025 Jun 8.
Factors influencing holistic lung cancer care among advanced/metastatic non-small cell lung cancer (NSCLC) patients in Asia-Pacific are understudied. We identified gaps in lung cancer care from patients, caregivers, and physicians in Australia, Japan, Mainland China, South Korea, and Taiwan.
Qualitative interviews and quantitative surveys were conducted among NSCLC patients with limited targeted treatment options, caregivers, and physicians. Patient-caregiver paired interviews ( = 15) were analyzed narratively and thematically; survey findings (70 patients, 106 physicians) were summarized descriptively. Descriptive analyses were performed with no formal hypothesis testing.
While patients (53-66%) felt able to care for their condition, 47% were unaware of genetic mutations and 46% perceived delays in diagnosis (41-44% were unaware of symptoms/severity). Most physicians (78-90%) prioritized treatment discussions, 51% decided for patients, and 69% encouraged patient-led decisions. Patients (61-77%) relied on physician decisions; 71-76% prioritizing reduced recurrence and minimal side effects over physician recommendations (53%). Although patients (66%) felt cared for by their doctors, 24-31% felt their mental/physical well-being was not proactively addressed.
This study identified significant gaps in lung cancer care, including patients' suboptimal disease and treatment knowledge, limited patient-physician shared decision-making, cancer stigma, and inadequate psychosocial support; underscoring the need for tailored interventions in Asia-Pacific.
亚太地区晚期/转移性非小细胞肺癌（NSCLC）患者的整体肺癌护理影响因素研究不足。我们发现了澳大利亚、日本、中国大陆、韩国和台湾地区患者、护理人员和医生在肺癌护理方面的差距。
对靶向治疗选择有限的NSCLC患者、护理人员和医生进行了定性访谈和定量调查。对患者-护理人员配对访谈（n = 15）进行了叙述性和主题性分析；对调查结果（70名患者、106名医生）进行了描述性总结。进行描述性分析，未进行正式的假设检验。
虽然患者（53%-66%）觉得自己能够照顾自己的病情，但47%的患者不知道基因突变情况，46%的患者认为诊断存在延迟（41%-44%的患者不知道症状/严重程度）。大多数医生（78%-90%）将治疗讨论列为优先事项，51%的医生为患者做决定，69%的医生鼓励患者主导决策。患者（61%-77%）依赖医生的决定；71%-76%的患者将降低复发率和最小化副作用置于医生建议（53%）之上。虽然患者（66%）觉得医生关心他们，但24%-31%的患者觉得他们的心理/身体健康没有得到主动关注。
本研究发现肺癌护理存在重大差距，包括患者对疾病和治疗的了解不足、患者与医生共同决策有限、癌症污名以及心理社会支持不足；强调亚太地区需要量身定制干预措施。
