Laurus Geraldo, Agustinus Agustinus, Pakpahan Cennikon, Lie Vellyana, Wen Maitra Djiang
Bocah Indonesia Fertility Centre, Tanggerang, Indonesia.
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Pan Afr Med J. 2025 Mar 3;50:64. doi: 10.11604/pamj.2025.50.64.45962. eCollection 2025.
intrauterine insemination (IUI) was selected as a treatment for infertility due to its simple method, affordability, and non-invasive. Intrauterine insemination had pregnancy rates after one cycle of IUI ranging between 8.2% and 15.1%. Candidates for IUI are couples facing specific infertility including cervical factors, ovulatory dysfunction, endometriosis, and ejaculation. Therefore, this study aimed to assess prognostic factors significantly affecting the outcome of IUI in Indonesia before the IUI procedure.
this study was conducted at Bocah Indonesia Fertility Clinic, Tangerang, and SMART IVF Anna Hospital, Bekasi, using an observational analytic method with a cohort retrospective design. Data were collected from infertile couples subjected to IUI between 2020 and 2024. The primary outcome measured was biochemical pregnancy, defined as a positive serum human chorionic gonadotropin (hCG) test following IUI. Prognostic factors for pregnancy were assessed and identified, while a predictive scoring system was developed using a multivariate analysis.
a total of 443 IUI cycles were evaluated and a pregnancy rate of 13.5% was observed. Multivariate analysis showed that pregnancy rates were influenced by the body mass index (BMI) of the male (<27.5 kg/m), age of the female (<30.5 years old), total progressive sperm count after sperm preparation (>15.81 million), first insemination, anti-mullerian hormone (AMH) level (>3.015 ng/mL), and endometrial thickness (>9.36 mm). A scoring system ranging from 0-9 was developed, with a probability of pregnancy from 1.31% to 55.16%, for scores 0 to 9, respectively.
the scoring system served as a tool designed specifically to evaluate the relationship between prognostic factors and post-IUI pregnancy rates.
宫内人工授精（IUI）因其方法简单、费用低廉且无创，被选作不孕症的一种治疗方法。宫内人工授精一个周期后的妊娠率在8.2%至15.1%之间。宫内人工授精的候选对象是面临特定不孕症的夫妇，包括宫颈因素、排卵功能障碍、子宫内膜异位症和射精问题。因此，本研究旨在评估在印度尼西亚进行宫内人工授精手术前显著影响宫内人工授精结果的预后因素。
本研究在坦格朗的印度尼西亚儿童生育诊所和勿加泗的SMART IVF安娜医院进行，采用队列回顾性设计的观察性分析方法。收集了2020年至2024年间接受宫内人工授精的不孕夫妇的数据。测量的主要结局是生化妊娠，定义为宫内人工授精后血清人绒毛膜促性腺激素（hCG）检测呈阳性。评估并确定妊娠的预后因素，同时使用多变量分析建立预测评分系统。
共评估了443个宫内人工授精周期，观察到妊娠率为13.5%。多变量分析表明，妊娠率受男性体重指数（BMI）（<27.5 kg/m）、女性年龄（<30.5岁）、精子制备后总活动精子数（>1581万）、首次授精、抗苗勒管激素（AMH）水平（>3.015 ng/mL）和子宫内膜厚度（>9.36 mm）的影响。开发了一个0至9分的评分系统，评分0至9分的妊娠概率分别为1.31%至55.16%。
该评分系统是专门设计用于评估预后因素与宫内人工授精后妊娠率之间关系的工具。
