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“开花状脑膜征”:肺癌早期软脑膜癌病的关键影像学线索——病例报告

The bloomy rind sign: A key imaging clue in early leptomeningeal carcinomatosis from lung cancer-A case report.

作者信息

Haddar Karim, Baddou Wadia, Haddar Leila, Laabadi Aicha, Ziani Hamid, Nasri Siham, Kamaoui Imane, Skiker Imane

机构信息

Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.

Department of Radiology, Mohammed VI University Hospital, Oujda, Morocco.

出版信息

Radiol Case Rep. 2025 May 15;20(8):3784-3788. doi: 10.1016/j.radcr.2025.04.072. eCollection 2025 Aug.

Abstract

Leptomeningeal carcinomatosis (LMC) is a rare but serious complication of advanced cancer, occurring in approximately 5% of patients with metastatic disease. It results from the dissemination of malignant cells into the cerebrospinal fluid and leptomeninges, often presenting with nonspecific neurological symptoms. We report a case of a 46-year-old male with no prior cancer history who presented with progressive headaches, vomiting, and cranial nerve deficits. MRI revealed the "bloomy rind sign"-a curvilinear T2-FLAIR hyperintensity surrounding the brainstem-suggestive of early LMC. Further imaging identified a hilar pulmonary mass consistent with lung cancer. Despite treatment with intrathecal chemotherapy and corticosteroids, the patient's condition deteriorated rapidly. This case underscores the diagnostic importance of the bloomy rind sign in early-stage LMC and highlights the need for heightened clinical suspicion and timely neuroimaging in patients with atypical neurological symptoms.

摘要

柔脑膜癌病(LMC)是晚期癌症一种罕见但严重的并发症,约5%的转移性疾病患者会出现。它是由恶性细胞扩散至脑脊液和柔脑膜引起的,常表现为非特异性神经症状。我们报告一例46岁男性,既往无癌症病史,出现进行性头痛、呕吐和颅神经功能缺损。磁共振成像(MRI)显示“花环状征”——脑干周围的曲线状T2液体衰减反转恢复序列(FLAIR)高信号,提示早期LMC。进一步影像学检查发现一个肺门部肺部肿块,符合肺癌表现。尽管接受了鞘内化疗和皮质类固醇治疗,患者病情仍迅速恶化。该病例强调了花环状征在早期LMC诊断中的重要性,并突出了对非典型神经症状患者提高临床怀疑度和及时进行神经影像学检查的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5de/12144463/22a3a45a416f/gr1.jpg

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