在B(CF)₃上以催化和化学计量模式将吡咯β选择性加成到缺电子烯烃上
β‑Selective Addition of Pyrroles to Electron-Deficient Alkenes in Both Catalytic and Stoichiometric Modes on B(CF).
作者信息
Sekine Seina, Kashiwa Miho, Kawakami Maho, Sonoda Takumi, Ono Arisa, Tsuchimoto Teruhisa
机构信息
Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
出版信息
ACS Omega. 2025 May 19;10(21):21510-21518. doi: 10.1021/acsomega.5c00371. eCollection 2025 Jun 3.
To the best of our knowledge, the addition of pyrroles to electron-deficient alkenes (APEda) via electrophilic aromatic substitution (SAr) has been reported to occur exclusively at the α-position of the pyrrole without any formation, even in trace amounts, of a β-adduct, β-. In sharp contrast to the prolonged immutable observation, we established an original SAr-based APEda (SAr-APEda) system applicable to both the catalytic and stoichiometric synthesis of β-.
据我们所知，通过亲电芳香取代反应（SAr）将吡咯加成到缺电子烯烃（APEda）上的反应据报道仅发生在吡咯的α位，没有任何β-加成物β-的生成，即使是痕量的也没有。与长期不变的观察结果形成鲜明对比的是，我们建立了一种基于SAr的原始APEda（SAr-APEda）体系，该体系适用于β-的催化和化学计量合成。
Zotero 插件