Alchurak Hussein, Almadhoun Aseel, Yılmaz İsmail, Ali Nour Raneem Mamoun, Kuzu Müslüm, Solmaz Hasan
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, 540011, Iraq.
Department of Medical Microbiology, The Institute of Graduate Programs, Karabük University, Karabük, 78050, Türkiye.
ChemistryOpen. 2025 Sep;14(9):e202500097. doi: 10.1002/open.202500097. Epub 2025 Jun 9.
In this study, two new 2,2'-bipyridine-4,4'-dicarboxamide ligands, namely N4,N4'-bis(pyridin-2-ylmethyl)-[2,2'-bipyridine]-4,4'-dicarboxamide (L1) and N4,N4'-bis(piperidin-2-ylmethyl)-[2,2'-bipyridine]-4,4'-dicarboxamide (L2), and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. Elemental analysis, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass techniques confirmed the structures of the synthesized compounds. The L1 structure is also determined by single-crystal X-ray diffraction. Antibacterial activities of ligands and metal complexes against resistant strains are investigated. The L2-Co complex demonstrates promising antibacterial qualities against these resistant strains, which is noteworthy. Additionally, enzyme inhibition studies are conducted to assess their potential therapeutic applications. The results show that the L2-Ni complex had the strongest inhibitory effect with IC values of 1.35 μM for lipase enzyme, 4.33 μM for acetylcholinesterase enzyme, and 6.42 μM for butyrylcholinesterase.
在本研究中，合成并表征了两种新型的2,2'-联吡啶-4,4'-二羧酰胺配体，即N4,N4'-双(吡啶-2-基甲基)-[2,2'-联吡啶]-4,4'-二羧酰胺(L1)和N4,N4'-双(哌啶-2-基甲基)-[2,2'-联吡啶]-4,4'-二羧酰胺(L2)，以及它们的Co(II)、Cu(II)和Ni(II)配合物。元素分析、傅里叶变换红外光谱、核磁共振和质谱技术证实了合成化合物的结构。L1的结构也通过单晶X射线衍射确定。研究了配体和金属配合物对耐药菌株的抗菌活性。L2-Co配合物对这些耐药菌株表现出有前景的抗菌特性，这一点值得注意。此外，还进行了酶抑制研究以评估它们潜在的治疗应用。结果表明，L2-Ni配合物具有最强的抑制作用，对脂肪酶的IC值为1.35 μM，对乙酰胆碱酯酶的IC值为4.33 μM，对丁酰胆碱酯酶的IC值为6.42 μM。
