van de Walle Gabriel, Morgantini Luca A, Long Bronwyn G, Arva Nicoleta C, Hentea Cristiana, Boucher Berry Claudia C, Osta Amanda, Johnson Emilie K
Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.
University of Illinois at Chicago, Department of Urology, Chicago, IL, USA.
Urol Case Rep. 2025 May 17;61:103071. doi: 10.1016/j.eucr.2025.103071. eCollection 2025 Jul.
Leydig cell tumors (LCTs) are rare in children and typically present with testicular masses and signs of early puberty. We report a case of a 6-year-old boy presenting solely with precocious pubic hair growth. Ultrasound revealed a small right testicular mass and elevated serum testosterone. Intra-operatively, hair growth was more prominent on the affected hemi-scrotum. Testis-sparing surgery confirmed a benign LCT with adjacent increased spermatogenesis. This is the first known report of ipsilateral pubic hair as a presenting sign of LCT. Localized androgen excess may be an early clinical indicator to guide timely diagnosis and treatment.
睾丸间质细胞瘤（LCTs）在儿童中罕见，通常表现为睾丸肿块和青春期早熟迹象。我们报告一例6岁男孩，仅表现为性早熟性阴毛生长。超声检查发现右侧睾丸有一个小肿块，血清睾酮升高。术中发现患侧阴囊半侧的毛发生长更为明显。保留睾丸手术证实为良性LCT，伴有相邻区域精子发生增加。这是已知首例将同侧阴毛作为LCT表现体征的报告。局部雄激素过多可能是指导及时诊断和治疗的早期临床指标。
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