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单侧阴毛生长:青春期前男孩潜在睾丸间质细胞瘤的旁分泌表现。

Unilateral pubic hair growth: a paracrine finding indicative of underlying leydig cell tumor in a prepubertal boy.

作者信息

van de Walle Gabriel, Morgantini Luca A, Long Bronwyn G, Arva Nicoleta C, Hentea Cristiana, Boucher Berry Claudia C, Osta Amanda, Johnson Emilie K

机构信息

Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.

University of Illinois at Chicago, Department of Urology, Chicago, IL, USA.

出版信息

Urol Case Rep. 2025 May 17;61:103071. doi: 10.1016/j.eucr.2025.103071. eCollection 2025 Jul.

Abstract

Leydig cell tumors (LCTs) are rare in children and typically present with testicular masses and signs of early puberty. We report a case of a 6-year-old boy presenting solely with precocious pubic hair growth. Ultrasound revealed a small right testicular mass and elevated serum testosterone. Intra-operatively, hair growth was more prominent on the affected hemi-scrotum. Testis-sparing surgery confirmed a benign LCT with adjacent increased spermatogenesis. This is the first known report of ipsilateral pubic hair as a presenting sign of LCT. Localized androgen excess may be an early clinical indicator to guide timely diagnosis and treatment.

摘要

睾丸间质细胞瘤(LCTs)在儿童中罕见,通常表现为睾丸肿块和青春期早熟迹象。我们报告一例6岁男孩,仅表现为性早熟性阴毛生长。超声检查发现右侧睾丸有一个小肿块,血清睾酮升高。术中发现患侧阴囊半侧的毛发生长更为明显。保留睾丸手术证实为良性LCT,伴有相邻区域精子发生增加。这是已知首例将同侧阴毛作为LCT表现体征的报告。局部雄激素过多可能是指导及时诊断和治疗的早期临床指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf9/12148672/79bbee302fca/gr1.jpg

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