Liu Xinyang, Lin Ruilang, Li Xinyue, He Mengjiang, Liu Yanbo, Hu Jianwei, Chen Weifeng, Li Quanlin, Yu Yongfu, Zhou Pinghong
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, P. R. China.
Gastroenterol Rep (Oxf). 2025 Jun 11;13:goaf042. doi: 10.1093/gastro/goaf042. eCollection 2025.
We aimed to investigate associations between three perinatal early-life factors and the risk of irritable bowel syndrome (IBS) in middle-aged and elderly people by using data from UK Biobank.
This is a population-based cohort study. Participants who had available data on early-life factors-namely maternal smoking around birth, being breastfed as a baby, and being one of a multiple birth and without IBS at the time of recruitment in UK Biobank-were included.
Among a total of 334,586 subjects, 93,908 (28.07%) were exposed to maternal smoking around birth, 243,778 (72.86%) were breastfed as a baby, and 7,551 (2.26%) were part of a multiple birth. During a median follow-up of 13.58 years, 7,254 participants developed IBS, at a median age of 63 years. The hazard ratios of IBS were 1.22 [95% confidence interval (CI), 1.16-1.28, <0.001], 0.92 (95% CI, 0.87-0.97, =0.002), and 1.22 (95% CI, 1.06-1.40, =0.006) for maternal smoking, breastfeeding, and multiple birth, respectively. The joint effect of any two of these three factors was related to added influence instead of interaction between them. The effect of maternal smoking on IBS was modified by age, while the modifiers of the effect of being breastfed as a baby on IBS were the age and sex of the offspring.
Participants exposed to maternal smoking around birth and being one of a multiple birth had a higher risk of IBS in middle-aged and elderly stages, while being breastfed as a baby had a protective effect against IBS. Future efforts should be made to validate the results.
我们旨在利用英国生物银行的数据，调查围产期三个早期生活因素与中老年人群肠易激综合征（IBS）风险之间的关联。
这是一项基于人群的队列研究。纳入了在英国生物银行招募时具有早期生活因素数据的参与者，这些因素包括出生前后母亲吸烟、婴儿期母乳喂养以及多胞胎之一且当时无IBS。
在总共334,586名受试者中，93,908名（28.07%）在出生前后暴露于母亲吸烟，243,778名（72.86%）婴儿期接受母乳喂养，7,551名（2.26%）为多胞胎之一。在中位随访13.58年期间，7,254名参与者患上IBS，中位发病年龄为63岁。母亲吸烟、母乳喂养和多胞胎对应的IBS风险比分别为1.22 [95%置信区间（CI），1.16 - 1.28，<0.001]、0.92（95% CI，0.87 - 0.97，=0.002）和1.22（95% CI，1.06 - 1.40，=0.006）。这三个因素中任意两个因素的联合效应与相加影响有关，而非它们之间的相互作用。母亲吸烟对IBS的影响随年龄而改变，而婴儿期母乳喂养对IBS影响的调节因素是后代的年龄和性别。
出生前后暴露于母亲吸烟以及作为多胞胎之一的参与者在中老年阶段患IBS的风险较高，而婴儿期母乳喂养对IBS有保护作用。未来应努力验证这些结果。
