Lin Kai Shiang, George Jensen, Ghanie Nazeera, Chandrakumar Harshith, Jayaraj Joseph, Gorantla Asher, John Sabu, Budzikowski Adam S
SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
J Med Cases. 2025 May;16(5):159-163. doi: 10.14740/jmc4350. Epub 2025 May 13.
New-onset complete heart block (CHB) occurring in a healthy young female is a relatively rare finding. We report a case of a 33-year-old female who was incidentally found to have CHB after presenting with a left tibial shaft fracture after a fall. Despite a past medical history of epilepsy, the maintenance of a long, seizure-free period coupled with the absence of neuromuscular weakness prompted a thorough investigation, and the etiology of the CHB was ultimately determined to be lacosamide (LCM), the antiseizure medication. The discontinuation of LCM resulted in spontaneous conversion to sinus rhythm, and an outpatient follow-up 4 weeks after discharge revealed no further episodes of falls, heart block, or other symptoms. We believe this is a rare presentation of LCM-induced CHB in an otherwise healthy young female.
健康年轻女性新发完全性心脏传导阻滞（CHB）是一种相对罕见的情况。我们报告一例33岁女性病例，该患者在跌倒后出现左胫骨干骨折，就诊时偶然发现患有CHB。尽管既往有癫痫病史，但长期无癫痫发作且无神经肌肉无力，促使进行了全面检查，最终确定CHB的病因是抗癫痫药物拉科酰胺（LCM）。停用LCM后自发转为窦性心律，出院后4周的门诊随访显示未再发生跌倒、心脏传导阻滞或其他症状。我们认为这是LCM诱发的CHB在一名原本健康的年轻女性中的罕见表现。
