Formica Caterina, Latella Desirée, Bonanno Lilla, Lombardo Facciale Antonino, Paladina Giuseppe, Leo Antonino, Pergolizzi Luca, Fonti Bartolo, Quartarone Angelo, Cellini Roberta, Calabrò Rocco Salvatore
IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
J Clin Med. 2025 Jun 5;14(11):3990. doi: 10.3390/jcm14113990.
Fatigue represents a hallmark symptom in Multiple Sclerosis (MS), but its diagnosis and clinical evaluation is difficult because it is described as a subjective feeling of exhausted physical and mental sensation. Studies have also shown that approaches based on assisted therapies and robotics, as well as the use of vibration, which are used to improve sensory integration, reduce fatigue. The primary outcome in this study is to evaluate the effects of the application of focal vibrations on the reduction in fatigue, muscle strength, and endurance in MS patients with moderate disability. The secondary outcome is to assess the effects on quality of life, cognitive status, and mood. We enrolled 40 MS patients. The study was designed as a parallel randomized controlled trial: 20 patients were assigned to the experimental group (EG), who received vibration training, and 20 to the control group (CG), who received traditional physical exercise. We found significant differences in the EG in fatigue, motor, and cognitive outcome and improvement of some aspects of quality of life (QoL). There are correlations between perceived multidimensional fatigue and cadence, step length, and health quality of life composite. Our study demonstrated the potential effectiveness of vibration training in balance, walking endurance, and reduction in the risk of falls in patients with Multiple Sclerosis. In addition, we added evidence about fatigue, non-motor outcomes, in particular promoting mental and physical QoL and individual life satisfaction. The name of the registry is clinicaltrial.gov; the number of registration id NCT05783999; and the date of registration is 14 March 2023.
疲劳是多发性硬化症（MS）的一个标志性症状，但其诊断和临床评估却很困难，因为它被描述为一种身心疲惫的主观感受。研究还表明，基于辅助疗法和机器人技术的方法，以及使用振动来改善感觉统合，可减轻疲劳。本研究的主要结果是评估局部振动对中度残疾的MS患者减轻疲劳、肌肉力量和耐力的影响。次要结果是评估对生活质量、认知状态和情绪的影响。我们招募了40名MS患者。该研究设计为平行随机对照试验：20名患者被分配到实验组（EG），接受振动训练，20名被分配到对照组（CG），接受传统体育锻炼。我们发现实验组在疲劳、运动和认知结果以及生活质量（QoL）某些方面的改善上存在显著差异。多维疲劳感知与步频、步长和健康生活质量综合指标之间存在相关性。我们的研究证明了振动训练对多发性硬化症患者的平衡、步行耐力和降低跌倒风险具有潜在有效性。此外，我们补充了关于疲劳、非运动结果的证据，特别是在促进心理和生理生活质量以及个人生活满意度方面。注册机构名称为clinicaltrial.gov；注册编号为NCT05783999；注册日期为2023年3月14日。
