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乳腺腺肌上皮瘤:活检时具有挑战性的诊断——病例报告及文献综述

Adenomyoepithelioma of the breast: a challenging diagnosis on biopsy-case report and literature review.

作者信息

Tazi Imane, Kouhkouh Bouchra, Ech-Charif Soumaya, Boujida Ismail, Khmou Mouna, Mahdi Youssef, El Khannoussi Basma

机构信息

Ibn Sina University Hospital Center Pathology, Rabat-Sale-Zemmour-Zaer, Rabat, Morocco.

Faculty of Medicine and Pharmacy of Rabat Pathology, Mohammed V University of Rabat, Rabat-Sale-Zemmour-Zaer, Rabat, Morocco.

出版信息

J Surg Case Rep. 2025 Jun 12;2025(6):rjaf372. doi: 10.1093/jscr/rjaf372. eCollection 2025 Jun.

Abstract

Adenomyoepithelioma of the breast (AME) is a rare tumor characterized by a dual proliferation of epithelial and myoepithelial cells. Although typically benign, AME carries a significant risk of recurrence and, in rare cases, malignant transformation. Its rarity, variable imaging features, and histological complexity make diagnosis challenging. Because it can closely mimic invasive breast carcinoma and overlap with other myoepithelial lesions, accurate histopathological assessment is essential. Here, we present the case of a 58-year-old woman with AME diagnosed on mastectomy following an initial misdiagnosis as carcinoma based on biopsy results. We review the literature and highlight the histopathological pitfalls associated with this rare entity.

摘要

乳腺腺肌上皮瘤(AME)是一种罕见肿瘤,其特征为上皮细胞和肌上皮细胞的双重增殖。尽管AME通常为良性,但具有显著的复发风险,在罕见情况下会发生恶性转化。其罕见性、多样的影像学特征以及组织学复杂性使得诊断具有挑战性。由于它可酷似浸润性乳腺癌并与其他肌上皮病变重叠,准确的组织病理学评估至关重要。在此,我们报告一例58岁患有AME的女性病例,该病例最初基于活检结果被误诊为癌,后在乳房切除术后确诊。我们回顾了文献并强调了与这种罕见实体相关的组织病理学陷阱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af72/12161491/e9914104d63f/rjaf372f1.jpg

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