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接种和未接种新冠疫苗的儿童龋齿、口腔黏膜干燥及唾液分泌情况的对比分析

A Comparative Analysis of Dental Caries, Mucosal Dryness, and Salivary Secretion in Pediatric COVID-19 Vaccinated and Unvaccinated Children.

作者信息

Shenoy Mahesh, Almarshed Mohammed, Alshamrani Abdulrahman Said S, Alzayer Hussain Ali M, Aleshaiwy Fares Sami A

机构信息

Department of OMFS and Diagnostic Sciences, Assistant Professor of Oral Pathology, College of Medicine and Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia.

Department of Dentistry, College of Medicine and Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia.

出版信息

J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S792-S794. doi: 10.4103/jpbs.jpbs_638_25. Epub 2025 Apr 12.

Abstract

INTRODUCTION

There have been isolated reports of oral negative outcomes after COVID-19 immunization in recent months, which calls for more research to determine a potential link to vaccine-induced immune response. Contrasting the salivary secretion, mucosal dryness, and dental caries of children who received the COVID-19 vaccine to those who did not is the goal of the research.

MATERIALS AND METHODS

Around 60 respondents participated in this cross-sectional research. Two groups of 30 folks each were formed. Group A comprised vaccinated kids, whereas Group B comprised unvaccinated kids. Following a thorough history taking of each kid (together with their parents), an intraoral assessment was conducted to look for any indications of caries or mucosal dryness. A quantitative analysis of salivary secretion ensued. The -test and Chi-square test were used for statistical analysis.

RESULTS

Vaccinated kids exhibited decreased salivary secretion and increased dental caries than those who did not, with a value of less than 0.0001. With a value equals 0.0002, the vaccinated individuals had greater levels mucosal dryness than the unvaccinated ones.

CONCLUSION

COVID-19 vaccine alters the rate of salivary production, leading to an increase in cases of poor oral health.

摘要

引言

近几个月有关于新冠病毒免疫接种后出现口腔不良后果的个别报道,这需要更多研究来确定其与疫苗诱导免疫反应之间的潜在联系。本研究的目的是对比接种新冠病毒疫苗的儿童与未接种儿童的唾液分泌、口腔黏膜干燥情况和龋齿情况。

材料与方法

约60名受访者参与了这项横断面研究。将他们分成两组,每组30人。A组为接种疫苗的儿童,B组为未接种疫苗的儿童。在对每个孩子(及其父母)进行全面的病史采集后,进行口腔内评估,以寻找龋齿或口腔黏膜干燥的迹象。随后对唾液分泌进行定量分析。采用t检验和卡方检验进行统计分析。

结果

接种疫苗的儿童与未接种疫苗的儿童相比,唾液分泌减少,龋齿增多,P值小于0.0001。接种疫苗的个体口腔黏膜干燥程度高于未接种者,P值等于0.0002。

结论

新冠病毒疫苗会改变唾液分泌速率,导致口腔健康不良情况增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2917/12156719/c7981bf4e4e8/JPBS-17-792-g001.jpg

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