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髋部骨折患者行半髋关节置换术的手术入路

Surgical approaches for inserting hemiarthroplasty of the hip in people with hip fractures.

作者信息

Morrell Aidan T, Lindsay Sarah E, Schabel Kathryn, Parker Martyn J, Griffin Xavier L

机构信息

Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, Oregon, USA.

Department of Orthopaedics, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, UK.

出版信息

Cochrane Database Syst Rev. 2025 Jun 13;6(6):CD016031. doi: 10.1002/14651858.CD016031.


DOI:10.1002/14651858.CD016031
PMID:40511667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12163977/
Abstract

RATIONALE: Hip fractures affect over 10 million people annually worldwide and are expected to increase with an ageing population, contributing significantly to morbidity, mortality, and healthcare costs. Hemiarthroplasty, a common treatment for displaced femoral neck fractures, accounts for more than half of hip fracture surgeries in older adults. However, the optimal surgical approach - anterior, lateral, or posterior - remains uncertain, with decisions often based on surgeon preference or institutional protocols. OBJECTIVES: To assess the effects of different surgical approaches for hemiarthroplasty in the treatment of hip fractures. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, and six other databases in November 2024. We also searched two trials registries, nine different conference proceedings, reference lists of included studies, and systematic reviews published within the last five years. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCTs) and quasi-RCTs in adults with hip fractures comparing different surgical approaches for hemiarthroplasty. We excluded studies of participants with high-energy hip fractures, fractures not associated with osteoporosis, or studies comparing hemiarthroplasty with total hip arthroplasty (THA). OUTCOMES: We were interested in a primary core outcome set: activities of daily living (ADL), health-related quality-of-life (HRQoL), mobility or functional status, mortality, and pain. Our secondary outcomes were complications, operative details and postoperative care outcomes. RISK OF BIAS: We used the Cochrane RoB 1 tool to assess risk of bias. SYNTHESIS METHODS: We performed meta-analyses using RevMan with a generic inverse-variance approach and random-effects models to calculate risk ratios (RRs), mean differences (MDs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs). We used GRADE to determine the certainty of evidence. INCLUDED STUDIES: We included 27 studies (23 RCTs, three quasi-RCTs, and one combined RCT/quasi-RCT) with a total of 3369 participants. The studies were conducted in Europe and Asia and published between 1981 and 2024. All studies but one focused on intracapsular fractures. The 'typical' included participant was a geriatric woman with an osteoporotic hip fracture treated with hip hemiarthroplasty who was ambulatory prior to injury and had a varying level of cognitive impairment at baseline. SYNTHESIS OF RESULTS: All but three studies were at high risk of detection bias and had unclear/high risk of bias in at least one domain. We downgraded many outcomes for imprecision, and for risk of bias where sensitivity analysis indicated the estimate was influenced in size or direction by studies with limitations. Anterior versus posterior approaches (7 studies, 455 participants) There was no evidence of a difference in ADL (MD 0.08, 95% CI -0.55 to 0.71; 1 study, 89 participants), mortality (RR 1.0, 95% CI 0.41 to 2.44; 3 studies, 242 participants), or pain (SMD -0.12, 95% CI -0.42 to 0.18; 2 studies, 171 participants) at three-month follow-up, but evidence was of very low-certainty. We found low-certainty evidence of improved early ability to ambulate independently with anterior approach hemiarthroplasty (RR 1.64, 95% CI 1.15 to 2.34; 2 studies, 161 participants). However, no evidence of a difference in measured functional status was shown at three-month follow-up (SMD 0.06, 95% -0.25 to 0.37; 3 studies, 158 participants). No studies reported on early HRQoL. Anterior versus lateral approaches (6 studies, 641 participants) We found no evidence of a difference in ADL (MD 3.08, 95% CI -14.95 to 21.1; 2 studies, 140 participants), or pain (MD -0.29, 95% CI -0.92 to 0.33; 4 studies, 282 participants) at three-month follow-up, but the evidence is very uncertain. There was low-certainty evidence of improved functional status with anterior approach hemiarthroplasty (MD 1.17, 95% CI 0.03 to 2.30; 2 studies, 142 participants). However, this did not reach a clinically important difference. We found that Trendelenburg gait may be reduced slightly with anterior approach hemiarthroplasty at three-month follow-up (RR 0.13, 95% CI 0.04 to 0.40; 1 study, 94 participants). We are unsure of the effect on early HRQoL as no studies reported the outcome, or for early mortality as no events were reported, resulting in a non-estimable effect size. Lateral versus posterior approaches (11 studies, 1840 participants) There was no evidence of a difference in early ADL (MD 0.05, 95% CI -0.33 to 0.43; 1 study, 297 participants), HRQoL (MD -0.03, 95% CI -0.09 to 0.03; 2 studies, 529 participants), functional status (SMD 0.09, 95% CI -0.36 to 0.55; 5 studies, 494 participants), or pain (SMD -0.07, 95% CI -0.41 to 0.27; 6 studies, 752 participants), but evidence was very low-certainty. We found low-certainty evidence of little to no difference between lateral and posterior approaches in mortality (RR 0.88, 95% CI 0.56 to 1.39; 4 studies, 1417 participants). AUTHORS' CONCLUSIONS: For people undergoing hemiarthroplasty for intracapsular hip fracture, the evidence is very uncertain regarding the effect of surgical approach on activities of daily living and pain within four months. There is little to no evidence of a difference in health-related quality of life, functional status, or mortality between approaches. There is currently insufficient evidence to determine whether anterior, lateral, or posterior approaches are a more appropriate option for hemiarthroplasty for hip fracture with respect to these outcomes. Further research is needed to improve the certainty of evidence, requiring better-powered trials, adherence to reporting standards, prospective trial registration, involvement of experienced surgeons, and blinded outcome assessment to reduce bias. Ensuring the inclusion of the core outcome set for hip fractures and follow-up of at least four months in all RCTs remains essential. FUNDING: This Cochrane review had no dedicated funding. REGISTRATION: Registration: Prospero CRD42024498914 Previous version available at: https://doi.org/10.1002/14651858.CD001707.

摘要

理论依据:全球范围内,每年有超过1000万人遭受髋部骨折,且随着人口老龄化,这一数字预计还会上升,给发病率、死亡率和医疗成本带来巨大影响。半髋关节置换术是治疗移位型股骨颈骨折的常用方法,在老年患者的髋部骨折手术中占比超过一半。然而,最佳手术入路——前路、外侧或后路——仍不明确,手术决策通常基于外科医生的偏好或机构协议。 目的:评估半髋关节置换术不同手术入路治疗髋部骨折的效果。 检索方法:我们于2024年11月检索了CENTRAL、MEDLINE、Embase和其他六个数据库。我们还检索了两个试验注册库、九个不同的会议论文集、纳入研究的参考文献列表以及过去五年内发表的系统评价。 纳入标准:我们纳入了比较半髋关节置换术不同手术入路的成人髋部骨折随机对照试验(RCT)和半随机对照试验。我们排除了高能髋部骨折患者、与骨质疏松无关的骨折患者的研究,或比较半髋关节置换术与全髋关节置换术(THA) 的研究。 结局指标:我们关注一个主要核心结局集:日常生活活动(ADL)、健康相关生活质量(HRQoL)、 mobility或功能状态、死亡率和疼痛。我们的次要结局是并发症、手术细节和术后护理结局。 偏倚风险:我们使用Cochrane RoB 1工具评估偏倚风险。 综合方法:我们使用RevMan进行荟萃分析,采用通用逆方差法和随机效应模型计算风险比(RRs)、平均差(MDs)或标准化平均差(SMDs),并给出95%置信区间(CIs)。我们使用GRADE来确定证据的确定性。 纳入研究:我们纳入了27项研究(23项RCT、3项半随机对照试验和1项RCT/半随机对照试验组合),共3369名参与者。这些研究在欧洲和亚洲进行,发表时间为1981年至2024年。除一项研究外,所有研究均聚焦于囊内骨折。纳入研究的 “典型” 参与者是一名接受半髋关节置换术治疗骨质疏松性髋部骨折的老年女性,受伤前可独立行走,基线时认知障碍程度各异。 结果综合:除三项研究外,所有研究均存在较高的检测偏倚风险,且至少在一个领域存在不明确/高偏倚风险。我们因结果不精确以及偏倚风险(敏感性分析表明估计值在大小或方向上受到有局限性研究的影响)而对许多结局进行了降级。前路与后路入路(7项研究,455名参与者) 在三个月随访时,没有证据表明ADL(MD 0.08,95%CI -0.55至0.71;1项研究,89名参与者)、死亡率(RR 1.0,95%CI 0.41至2.44;3项研究,242名参与者)或疼痛(SMD -0.12,95%CI -0.42至0.18;2项研究,171名参与者)存在差异,但证据的确定性非常低。我们发现低确定性证据表明前路半髋关节置换术可改善早期独立行走能力(RR 1.64,95%CI 1.15至2.34;2项研究,161名参与者)。然而,在三个月随访时,没有证据表明测量的功能状态存在差异(SMD 0.06,95% -0.25至0.37;3项研究,158名参与者)。没有研究报告早期HRQoL情况。前路与外侧入路(6项研究,641名参与者) 在三个月随访时,我们没有发现ADL(MD 3.08,95%CI -14.95至21.1;2项研究,140名参与者)或疼痛(MD -0.29,95%CI -0.92至0.33;4项研究,282名参与者)存在差异的证据,但证据非常不确定。有低确定性证据表明前路半髋关节置换术可改善功能状态(MD 1.17,95%CI 0.03至2.30;2项研究,142名参与者)。然而,这并未达到临床重要差异。我们发现,在三个月随访时,前路半髋关节置换术可能会使Trendelenburg步态略有减轻(RR 0.13,95%CI 0.04至0.40;1项研究,94名参与者)。由于没有研究报告该结局,我们不确定对早期HRQoL的影响,也不确定对早期死亡率的影响,因为没有报告相关事件,导致效应大小无法估计。外侧与后路入路(11项研究,1840名参与者) 没有证据表明早期ADL(MD 0.05,95%CI -0.33至0.43;1项研究,297名参与者)、HRQoL(MD -0.03,95%CI -0.09至0.03;2项研究,529名参与者)、功能状态(SMD 0.09,95%CI -0.36至0.55;5项研究,494名参与者)或疼痛(SMD -0.07,95%CI -0.41至0.27;6项研究,752名参与者)存在差异,但证据的确定性非常低。我们发现低确定性证据表明外侧与后路入路在死亡率方面几乎没有差异(RR 0.88,95%CI 0.56至1.39;4项研究,1417名参与者)。 作者结论:对于接受囊内髋部骨折半髋关节置换术的患者,手术入路对四个月内日常生活活动和疼痛影响的证据非常不确定。不同入路在健康相关生活质量、功能状态或死亡率方面几乎没有差异的证据。目前没有足够的证据来确定前路、外侧或后路入路对于髋部骨折半髋关节置换术来说,在这些结局方面哪种更合适。需要进一步研究以提高证据的确定性,这需要开展更有说服力的试验、遵循报告标准、进行前瞻性试验注册、让经验丰富的外科医生参与,并采用盲法结局评估以减少偏倚。确保在所有RCT中纳入髋部骨折核心结局集并进行至少四个月的随访仍然至关重要。 资金来源:本Cochrane综述没有专项资金。 注册信息:注册:Prospero CRD42024498914 先前版本可在:https://doi.org/10.1002/14651858.CD001707获取。

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本文引用的文献

[1]
Periprosthetic bone mineral density, assessed using dual energy x-ray absorptiometry, following arthroplasty in patients with femoral neck fracture: 5-year outcomes of a randomized controlled trial.

J Int Med Res. 2024-9

[2]
Clinical effectiveness of a modified muscle sparing posterior technique compared with a standard lateral approach in hip hemiarthroplasty for displaced intracapsular fractures (HemiSPAIRE): a multicenter, parallel-group, randomized controlled trial.

BMJ Surg Interv Health Technol. 2024-6-17

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[10]
Increased risk of high-grade heterotopic ossification using direct lateral approach versus a muscle-sparing anterolateral approach to the hip: radiological results from a randomised trial in patients with a femoral neck fracture treated with hemiarthroplasty.

Hip Int. 2023-7

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