Vukelic Jelena, Marzic Diana, Liovic Anja, Manestar Dubravko, Anic Dubravka Matesa
Department of Audiology and Phoniatrics, Clinical Hospital Center Rijeka, Kresimirova 42, 51000, Rijeka, Croatia; University of Rijeka Faculty of Medicine, Brace Branchetta 20, 51000, Rijeka, Croatia.
University of Rijeka, Speech and Language Pathology, Radmile Matejcic 2, 51000, Rijeka, Croatia.
Arch Gerontol Geriatr. 2025 Oct;137:105932. doi: 10.1016/j.archger.2025.105932. Epub 2025 Jun 6.
To analyze the effect of aging on hearing outcomes following treatment for sudden sensorineural hearing loss (SSNHL).
This retrospective study reviewed records of 106 SSNHL patients categorized into younger (<65 years) and older (≥65 years). Hearing outcomes and related factors including sex, absolute gain, treatment timing, Hyperbaric Oxygen Therapy (HBOT), audiogram type, and contralateral ear thresholds were examined.
Treatment outcomes between age groups showed no statistically significant difference (p = 0.053), though younger age was consistently linked to better recovery. A significant negative correlation between age and absolute hearing gain was observed (r = -0.296, p < 0.05). Younger females showed superior outcomes compared to younger males (p < 0.05). Early treatment predicted better recovery (χ² = 9.04, p < 0.01). A normal contralateral ear threshold was associated with better recovery (p < 0.05). A multivariate logistic regression model was developed (AUC = 0.781). Symptom duration (p < 0.05) and intratympanic therapy (p < 0.05) were significant predictors of hearing outcomes. Age was not a significant independent predictor (p = 0.054), but it improved model fit, supporting its clinical relevance.
The timing of treatment initiation is important for SSNHL prognosis. Although age did not reach statistical significance in the multivariate model, its consistent association with better outcomes and contribution to model fit highlight its continued clinical relevance. Early intervention is the key predictor of recovery, reinforcing the value of age-informed, personalized treatment strategies in managing SSNHL.
分析年龄对突发性感音神经性听力损失(SSNHL)治疗后听力结果的影响。
这项回顾性研究回顾了106例SSNHL患者的记录,这些患者被分为年轻组(<65岁)和老年组(≥65岁)。检查了听力结果及相关因素,包括性别、绝对增益、治疗时机、高压氧治疗(HBOT)、听力图类型和对侧耳阈值。
年龄组之间的治疗结果无统计学显著差异(p = 0.053),尽管年轻患者始终与更好的恢复相关。观察到年龄与绝对听力增益之间存在显著负相关(r = -0.296,p < 0.05)。年轻女性的治疗结果优于年轻男性(p < 0.05)。早期治疗预示着更好的恢复(χ² = 9.04,p < 0.01)。对侧耳阈值正常与更好的恢复相关(p < 0.05)。建立了多因素逻辑回归模型(AUC = 0.781)。症状持续时间(p < 0.05)和鼓室内治疗(p < 0.05)是听力结果的显著预测因素。年龄不是显著的独立预测因素(p = 0.054),但它改善了模型拟合,支持其临床相关性。
开始治疗的时机对SSNHL的预后很重要。虽然年龄在多因素模型中未达到统计学显著性,但其与更好结果的持续关联以及对模型拟合的贡献突出了其持续的临床相关性。早期干预是恢复的关键预测因素,强化了在管理SSNHL中基于年龄的个性化治疗策略的价值。