Isaev I M, Shvalev V N
Arkh Anat Gistol Embriol. 1985 Jun;88(6):30-5.
By means of classical neurohistological techniques and methods for revealing cholinergic and adrenergic neural plexuses, the development of pulmonary innervation has been studied in embryos and fetuses of the human being and rabbit. The mediatory stage in development of the pulmonary innervation begins on the 3d month of the human intrauterine development. The next important stages are the middle of the prenatal development and the 7th month of pregnancy, when an essential complication of the lung innervation takes place. By birth the neural apparatus of the human and rabbit lung is mainly formed, nevertheless, in 15% of newborns its underdevelopment occurs. This may be a predisposing factor for development of certain pathological processes, in particular, pneumosclerosis, and is demonstration of defective formation of the pulmonary parenchyma in some newborns. The principle on coincidence of the beginning of the mediatory stage in the development of the neural plexuses and the beginning of the fetal stage are supposed by the analysis of the pulmonary innervation development in the rabbit.
借助经典神经组织学技术以及用于揭示胆碱能和肾上腺素能神经丛的方法，对人类和兔子胚胎及胎儿的肺神经支配发育进行了研究。肺神经支配发育的中介阶段始于人类子宫内发育的第3个月。接下来的重要阶段是产前发育中期和妊娠第7个月，此时肺神经支配发生了重要变化。到出生时，人类和兔子肺的神经装置已基本形成，然而，15%的新生儿会出现其发育不全的情况。这可能是某些病理过程，特别是肺硬化症发生发展的一个易感因素，并且表明一些新生儿的肺实质形成存在缺陷。通过对兔子肺神经支配发育的分析推测，神经丛发育的中介阶段开始与胎儿期开始相吻合的原理。
