为期三个月的辅助瑜伽干预对1型糖尿病青少年血糖控制的影响：一项随机对照试验。
The impact of three months of adjuvant yoga intervention on glycemic control among adolescents with type 1 diabetes: a randomized control trial.
作者信息
Maurya Sonu, Patil Suchitra, Singh Amit, Rani Indu, Kaur Navneet, Mohanty Sriloy, Anand Akshay, Nagarathna Raghuram
机构信息
Department of Yoga and Life Science, S-VYASA University, Prashanthi Kutiram, Kalluballu Post, Jigani, Bangalore, Karnataka, 560105, India.
Interdisciplinary Centre for Swami Vivekananda Studies Panjab University, Chandigarh, India.
出版信息
Diabetol Metab Syndr. 2025 Jun 16;17(1):216. doi: 10.1186/s13098-025-01632-9.
BACKGROUND
There is growing evidence that shows the benefits of yoga on people with diabetes. The benefit of yoga for people with Type 2 Diabetes has been proven. Incorporating yoga in daily life helps to attain glycaemic control and reduces the risk of complications in people with diabetes especially in the Type 2 Diabetes Mellitus (T2DM) field. However, limited work is done for yoga on Type 1 Diabetes Mellitus (T1DM). The current trial aimed to investigate the effect of yoga intervention on glycemic control and Quality of Life (QoL) among adolescents with T1DM.
METHODS
In this trial, 92 T1DM subjects with mean age of 13.35 ± 2.41 years were recruited and randomly allocated to either yoga or control arm with an allocation ratio of 1:1. The control arm received standard care whereas; the yoga arm received additional tailored yoga sessions for three months. Venous blood samples were collected for HbA1c and average blood glucose (ABG) along with daily insulin requirements, PedsQL-3.0, PedsQL-4.0, Kutcher Adolescent Depression Scale, Fear of hypoglycaemia questionnaire at baseline and post-intervention. Both per-protocol and Intention-to-treat (ITT) analysis were done.
RESULTS
Out of 92 participants recruited, only 46 could complete the trial (yoga arm: n = 25). The per-protocol analysis showed a significant reduction in the HbA1c levels (14.68% vs. -12.90%;p < 0.001) as well as in the ABG levels (17.72% vs. -15.65%;p < 0.001) in the intervention arm when compared to the control arm. An ITT analysis of the primary objectives also yielded similar results. Further, Insulin requirements (p = 0.04) and hyperglycaemia frequency (p = 0.02) were significantly reduced in the yoga arm however, it lacked significance in between-group analysis. Fear of hypoglycaemia was reduced by 23.9% in the intervention group while it was 3% in the control group which was significant. Significant improvement in QoL, depression, and level of physical activity were observed following yoga intervention compared to the control group.
CONCLUSION
The three-month adjuvant yoga intervention was associated with an improved glycaemic control and QoL among adolescents with T1DM.
背景
越来越多的证据表明瑜伽对糖尿病患者有益。瑜伽对2型糖尿病患者的益处已得到证实。将瑜伽融入日常生活有助于实现血糖控制，并降低糖尿病患者尤其是2型糖尿病（T2DM）患者并发症的风险。然而，针对1型糖尿病（T1DM）患者进行的瑜伽相关研究较少。当前试验旨在调查瑜伽干预对T1DM青少年患者血糖控制及生活质量（QoL）的影响。
方法
在本试验中，招募了92名平均年龄为13.35±2.41岁的T1DM受试者，并以1:1的分配比例随机分为瑜伽组或对照组。对照组接受标准护理，而瑜伽组额外接受为期三个月的定制瑜伽课程。在基线和干预后采集静脉血样本，检测糖化血红蛋白（HbA1c）、平均血糖（ABG）以及每日胰岛素需求量，并使用儿童生活质量量表（PedsQL-3.0、PedsQL-4.0）、库彻青少年抑郁量表、低血糖恐惧问卷进行评估。同时进行符合方案分析和意向性分析（ITT）。
结果
在招募的92名参与者中，只有46人能够完成试验（瑜伽组：n = 25）。符合方案分析显示，与对照组相比，干预组的HbA1c水平显著降低（14.68% vs. -12.90%；p < 0.001），ABG水平也显著降低（17.72% vs. -15.65%；p < 0.001）。ITT分析的主要目标也得出了类似结果。此外，瑜伽组的胰岛素需求量（p = 0.04）和高血糖发生频率（p = 0.02）显著降低，但在组间分析中缺乏显著性差异。干预组的低血糖恐惧降低了23.9%，而对照组仅降低了3%，差异显著。与对照组相比，瑜伽干预后患者的生活质量、抑郁状况和身体活动水平有显著改善。
结论
为期三个月的辅助瑜伽干预与T1DM青少年患者血糖控制改善及生活质量提高相关。
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