Hong Subeen, Jung Young Mi, Seol Hyun-Joo, Na Sunghun, Bae Jin Gon, Ahn Ki Hoon, Kwon Hayan, Sung Ji-Hee, Choi Soo Ran, Kim Seung Cheol, Lee Kyung A, Kim Hee Sun, Kim Mi Ju, Song Ji Eun, Hwang Han Sung, Jun Jong Kwan, Kim So Yeon, Won Hye-Sung, Lee Mi-Young, Ko Hyun Sun
Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Mol Genet Genomic Med. 2025 Jun;13(6):e70116. doi: 10.1002/mgg3.70116.
The aim of our study was to investigate the clinical characteristics, discrepancies in postnatal diagnosis, and outcomes of prenatally diagnosed arachnoid cysts without extra-CNS anomalies.
This study was a multi-center retrospective cohort study from 16 participating university hospitals in South Korea, with patient data pooled from January 2010 to December 2019. This study focused on cases with prenatally diagnosed arachnoid cysts and analyzed postnatal diagnoses related to CNS anomalies, the need for surgery, and clinical outcomes.
Thirty-seven fetuses with fetal arachnoid cysts were ultimately included in our analysis. These included 27 supratentorial cysts and 10 posterior fossa cysts, with 11 cases (29.7%) presenting associated CNS anomalies. The most common associated anomalies were ventriculomegaly (18.9%) and callosal abnormalities (10.8%). No chromosomal abnormalities were detected during antenatal care. Postnatal regression was observed in 14.8% of supratentorial cysts and 10.0% of posterior fossa cysts. Neurologic complications, present in 21.6% of all cases, were more prevalent in cases with associated CNS anomalies compared to isolated arachnoid cysts.
In cases diagnosed with prenatal arachnoid cysts, ventriculomegaly and callosal anomalies are the most commonly associated CNS anomalies. The presence of additional CNS anomalies is the most critical factor affecting neurologic outcomes.
我们研究的目的是调查产前诊断为蛛网膜囊肿且无中枢神经系统外异常的临床特征、产后诊断差异及预后情况。
本研究是一项来自韩国16家参与研究的大学医院的多中心回顾性队列研究,收集了2010年1月至2019年12月的患者数据。本研究聚焦于产前诊断为蛛网膜囊肿的病例,分析与中枢神经系统异常相关的产后诊断、手术需求及临床结局。
最终37例胎儿蛛网膜囊肿纳入我们的分析。其中包括27例幕上囊肿和10例后颅窝囊肿,11例(29.7%)伴有相关中枢神经系统异常。最常见的相关异常是脑室扩大(18.9%)和胼胝体异常(10.8%)。产前检查期间未检测到染色体异常。幕上囊肿14.8%和后颅窝囊肿10.0%观察到产后囊肿消退。所有病例中21.6%出现神经并发症,与孤立性蛛网膜囊肿相比,伴有相关中枢神经系统异常的病例中神经并发症更常见。
在产前诊断为蛛网膜囊肿的病例中,脑室扩大和胼胝体异常是最常见的相关中枢神经系统异常。额外中枢神经系统异常的存在是影响神经结局的最关键因素。