Naser Abbas Abdulameer, Dehkordi Khosro Jalali, Radhi Mahmoud Nasser, Taghian Farzaneh, Chitsaz Ahmad
Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University,Isfahan, Iran.
Faculty of Physical Education and Sports Sciences, University of Kufa, Iraq.
Int J Prev Med. 2025 May 28;16:35. doi: 10.4103/ijpvm.ijpvm_353_24. eCollection 2025.
Parkinson's disease (PD) leads to a significant decrease in brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). This study explores the effect of 12 weeks of multimodal exercise on the levels of BDNF and GDNF in patients with PD.
The study is a quasiexperimental study with random sampling. It was conducted in 2024 at Isfahan. Demographic data were collected using the demographic questionnaire outlined in the Methods section. Thirty patients were randomly divided into two equal groups of multimodal exercise and control, with no significant differences in age, weight, and height. The variables of BDNF and GDNF were assessed in pre- and post-tests. Multimodal exercise was performed 5 days a week for 12 weeks. Data were analyzed using covariance and -test at a significant level of < 0.05.
The study observed significant differences in BDNF and GDNF, among two groups of PD ( < 0.01). Moreover, the levels of BDNF and GDNF were significantly higher in the PD + Training group compared to the PD group ( < 0. 01).
Given that multimodal exercises are effective in increasing BDNF and GDNF in individuals with PD, it is recommended to incorporate the benefits of these exercises into physical rehabilitation programs. Therefore, the combined approach of multimodal exercises (resistance, aerobic, and balance) is recommended as the most effective complementary therapeutic strategy for PD.
帕金森病（PD）会导致脑源性神经营养因子（BDNF）和胶质细胞源性神经营养因子（GDNF）显著减少。本研究探讨了为期12周的多模式运动对帕金森病患者BDNF和GDNF水平的影响。
本研究为随机抽样的半实验性研究。于2024年在伊斯法罕进行。使用方法部分概述的人口统计学问卷收集人口统计数据。30名患者被随机分为多模式运动组和对照组，每组人数相等，两组在年龄、体重和身高方面无显著差异。在测试前和测试后评估BDNF和GDNF变量。多模式运动每周进行5天，共12周。数据采用协方差分析和t检验进行分析，显著性水平为<0.05。
研究观察到两组帕金森病患者在BDNF和GDNF方面存在显著差异（<0.01）。此外，与帕金森病组相比，帕金森病+训练组的BDNF和GDNF水平显著更高（<0.01）。
鉴于多模式运动对提高帕金森病患者的BDNF和GDNF有效，建议将这些运动的益处纳入身体康复计划。因此，建议采用多模式运动（抗阻、有氧和平衡）相结合的方法作为帕金森病最有效的辅助治疗策略。
