Shen Jianlin, Bin Wenying, Lin Xiaoning, Lai Yue, Lin Xuan, Guan Taiyuan, Liu Huan
Central Laboratory, Affiliated Hospital of Putian University, Putian, Fujian, 351100, People's Republic of China.
Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, 351100, People's Republic of China.
Int J Nanomedicine. 2025 Jun 9;20:7251-7270. doi: 10.2147/IJN.S514516. eCollection 2025.
The Klotho protein, encoded by the KL gene, has garnered significant attention as a pivotal biomolecule in the field of aging research. Its expression levels are closely correlated with both lifespan and overall health status, exerting influence over critical physiological processes such as metabolic homeostasis, oxidative stress response, and inflammation modulation. This review aims to systematically examine the multifaceted roles of Klotho within the context of aging and its implications for various age-associated disorders. We highlight the emerging evidence suggesting that Klotho may serve as a key regulator in age-related pathologies, including cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Furthermore, we explore the potential of Klotho as a therapeutic target, positing that interventions aimed at enhancing Klotho activity could offer novel strategies for alleviating the health burdens experienced by the aging population.
由KL基因编码的Klotho蛋白，作为衰老研究领域的关键生物分子，已引起了广泛关注。其表达水平与寿命和整体健康状况密切相关，对代谢稳态、氧化应激反应和炎症调节等关键生理过程产生影响。本综述旨在系统地研究Klotho在衰老背景下的多方面作用及其对各种与年龄相关疾病的影响。我们强调了新出现的证据，表明Klotho可能是与年龄相关病理的关键调节因子，包括心血管疾病、神经退行性疾病和代谢综合征。此外，我们探讨了Klotho作为治疗靶点的潜力，认为旨在增强Klotho活性的干预措施可能为减轻老年人群的健康负担提供新策略。
