Morales-Rivero Alonso, Garcia-Cordero Indira, Khoja Abeer, Vargas-Gonzalez Juan-Camilo, Couto Blas, Antwi Jeffrey, Sasitharan Johnathan, Bhakta Puja, Kovacs Gabor G, Fox Susan, Tang-Wai David F, Lang Anthony E, Tartaglia Maria Carmela
University Health Network Memory Clinic, Toronto, Ontario, Canada.
ABC Medical Center, Mexico City, Mexico.
Eur J Neurol. 2025 Jun;32(6):e70248. doi: 10.1111/ene.70248.
Progressive supranuclear paralysis (PSP) is an atypical parkinsonian disorder associated with oculomotor features, motor disturbances, along with cognitive problems and neuropsychiatric symptoms. Quality of life (QoL) is often assessed in relation to the motor symptoms. Our aim was to investigate the impact of neuropsychiatric symptoms on QoL.
We used data from 40 patients meeting criteria for probable PSP from the Rossy PSP Centre. Motor and neuropsychiatric symptoms, cognition, functionality, disease severity, and quality of life were examined using validated scales. We performed a linear regression model using multiple imputations with chained equations with 500 sets.
We found that lower quality of life scores were related to higher anxiety and depression and the interaction between these two. There was a decrease in the quality of life of -3.7 points (95% CI: -6.1 to -1.1) for every one point of increase on the depression scale; there was a decrease in the quality of life scale of -4.3 points for each point of increase on the depression score (95% CI: -7.8 to -0.8). The fully adjusted linear model showed that motor scores, cognition, and other neuropsychiatric symptoms were not associated with quality of life.
We found that both anxiety and depression significantly impacted quality of life. Given the prevalence of non-motor manifestations in PSP, these results emphasize the importance of comprehensive evaluations to better capture the multi-faceted impairments seen in PSP that have a meaningful impact on the patient's life.
进行性核上性麻痹（PSP）是一种非典型帕金森氏症，伴有眼球运动功能障碍、运动紊乱，以及认知问题和神经精神症状。生活质量（QoL）通常根据运动症状进行评估。我们的目的是研究神经精神症状对生活质量的影响。
我们使用了来自罗西PSP中心40名符合可能PSP标准患者的数据。使用经过验证的量表对运动和神经精神症状、认知、功能、疾病严重程度和生活质量进行了检查。我们使用链式方程的多重插补法和500组数据进行了线性回归模型分析。
我们发现较低的生活质量得分与较高的焦虑和抑郁以及这两者之间的相互作用有关。抑郁量表每增加1分，生活质量得分下降3.7分（95%CI：-6.1至-1.1）；抑郁得分每增加1分，生活质量量表下降4.3分（95%CI：-7.8至-0.8）。完全调整后的线性模型显示，运动得分、认知和其他神经精神症状与生活质量无关。
我们发现焦虑和抑郁均对生活质量有显著影响。鉴于PSP中非运动表现的普遍性，这些结果强调了全面评估的重要性，以便更好地捕捉PSP中对患者生活有重大影响的多方面损害。
