Liu Yali, Lin Siya, Bai Meirong, Yi Huochun
Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People's Republic of China.
School of Nursing, Fujian Medical University, Fuzhou, Fujian, 350122, People's Republic of China.
Cancer Manag Res. 2025 Jun 12;17:1099-1111. doi: 10.2147/CMAR.S507420. eCollection 2025.
Symptom clusters in cancer symptom management research, providing a scientific basis for developing effective strategies for symptom assessment and intervention aimed at improving patient quality of life and survival.
To analyze symptom clusters in postoperative lung cancer patients, examine its influenced factor, and explore the relationship between postoperative symptom clusters and functional status in lung cancer patients.
Between August 2023 and February 2024, 441 lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery at a tertiary hospital in Xiamen were selected. Data collection included a general information questionnaire, the Postoperative Patient-Reported Outcomes Scale for Early-Stage Lung Cancer Patients, the Tampa Scale for Kinesiophobia (TSK), and the Karnofsky Performance Status Scale (KPSS). Latent class analysis was employed to categorize the self-reported outcomes. Statistical analyses were performed on the relevant factors.
The self-reported postoperative symptoms in lung cancer patients were divided into two groups: high-symptom burden and low-symptom burden. Significant differences were observed between these groups concerning surgery duration, kinesiophobia score, personality traits, KPSS, and the use of analgesic pumps ( <0.005). After adjusting for sex, age, lifestyle, and health status, a multi-model approach confirmed a significant inverse relationship between higher KPSS levels and higher symptom burden ( < 0.001). High-symptom levels are negatively associated with functional status ( <0.005).
Postoperative symptom clusters in lung cancer patients can be specifically categorized into high and low-symptom burdens. Surgery duration, kinesiophobia scores, personality traits, KPSS, and the use of analgesic pumps are significant risk factors affecting symptom burden. Postoperative symptom cluster assessment provides a scientific basis for developing effective management strategies, which may improve functional recovery and long-term outcomes in lung cancer patients.
癌症症状管理研究中的症状群，为制定旨在改善患者生活质量和生存率的症状评估及干预有效策略提供科学依据。
分析肺癌术后患者的症状群，探讨其影响因素，并探究肺癌患者术后症状群与功能状态之间的关系。
选取2023年8月至2024年2月在厦门某三级医院胸外科接受手术治疗的441例肺癌患者。数据收集包括一般信息问卷、早期肺癌患者术后患者报告结局量表、坦帕运动恐惧量表（TSK）和卡氏功能状态量表（KPSS）。采用潜在类别分析对自我报告结局进行分类。对相关因素进行统计分析。
肺癌患者自我报告的术后症状分为两组：高症状负担组和低症状负担组。两组在手术时长、运动恐惧评分、人格特质、KPSS以及镇痛泵使用情况方面存在显著差异（<0.005）。在调整性别、年龄、生活方式和健康状况后，多模型方法证实较高的KPSS水平与较高的症状负担之间存在显著负相关（<0.001）。高症状水平与功能状态呈负相关（<0.005）。
肺癌患者术后症状群可具体分为高症状负担组和低症状负担组。手术时长、运动恐惧评分、人格特质、KPSS以及镇痛泵使用情况是影响症状负担的重要危险因素。术后症状群评估为制定有效的管理策略提供科学依据，这可能改善肺癌患者的功能恢复和长期预后。
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