根据Ki-67增殖指数的中枢神经细胞瘤的影像学特征。
Imaging characteristics of central neurocytomas according to Ki-67 proliferation index.
作者信息
Zhang Yan-Li, Liu Ling, Li Wei, Ran Chao, Luo Yu-Qi
机构信息
Department of Clinical Pharmacy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Obstetrics Department, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
出版信息
Front Oncol. 2025 Jun 3;15:1601817. doi: 10.3389/fonc.2025.1601817. eCollection 2025.
PURPOSE
To evaluate the imaging characteristics of central neurocytoma (CN) with different Ki-67 indices and reveal its biological behavior.
MATERIALS AND METHODS
Sixty-nine cases of intraventricular CN confirmed by histopathology were collected retrospectively. According to Ki-67 indices, they were divided into CNs with high Ki-67 (30 cases) and CNs with low Ki-67 (39 cases). Their clinical and imaging findings were compared and analyzed.
RESULTS
Compared to CNs with low Ki-67, CNs with high Ki-67 were larger (P < 0.001) and more solid (P = 0.019). Restricted diffusion (P = 0.020), CT hyperdensity (P < 0.001), abnormal vessels (P = 0.018), and marked MRI enhancement (P < 0.001) were more common in CNs with high Ki-67.
CONCLUSION
Different Ki-67 indices could affect the imaging characteristics of CNs. Tumor size, radiologic solidity, abnormal vessels, and marked MRI enhancement suggested CNs with high Ki-67. Combining these imaging characteristics and Ki-67 indices offered meaningful insights into their clinical diagnosis and biological behavior.
目的
评估不同Ki-67指数的中枢神经细胞瘤（CN）的影像学特征，并揭示其生物学行为。
材料与方法
回顾性收集69例经组织病理学确诊的脑室内CN病例。根据Ki-67指数，将其分为高Ki-67指数的CN（30例）和低Ki-67指数的CN（39例）。比较并分析它们的临床和影像学表现。
结果
与低Ki-67指数的CN相比，高Ki-67指数的CN体积更大（P < 0.001）且实性成分更多（P = 0.019）。高Ki-67指数的CN中，扩散受限（P = 0.020）、CT高密度（P < 0.001）、异常血管（P = 0.018）及MRI明显强化（P < 0.001）更为常见。
结论
不同的Ki-67指数可影响CN的影像学特征。肿瘤大小、放射学实性、异常血管及MRI明显强化提示为高Ki-67指数的CN。结合这些影像学特征和Ki-67指数有助于深入了解其临床诊断及生物学行为。
Zotero 插件