Abdelhamid S, Lewicka S, Vecsei P, Winter J
Cardiology. 1985;72 Suppl 1:102-6. doi: 10.1159/000173954.
In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remained in the normal range. As the possible cause for this observation, the role of intestinal bacteria was considered which may transform tetrahydroaldosterone into 21-deoxytetrahydroaldosterone. Using a 21-deoxytetrahydroaldosterone radioimmunoassay, this hypothesis could be confirmed. The sums of the urinary 21-deoxytetrahydroaldosterone and tetrahydroaldosterone excretions revealed to be of better diagnostic value than the tetrahydroaldosterone values alone.
我们小组早期的研究表明，尿中四氢醛固酮排泄量对原发性醛固酮增多症的诊断而言，是比醛固酮 - 18 - 葡萄糖醛酸苷（“尿醛固酮”）更可靠的检测方法。然而，在一些原发性醛固酮增多症患者中，即使四氢醛固酮值仍处于正常范围。作为这一观察结果的可能原因，肠道细菌的作用被考虑在内，其可能将四氢醛固酮转化为21 - 脱氧四氢醛固酮。通过使用21 - 脱氧四氢醛固酮放射免疫测定法，这一假设得以证实。尿中21 - 脱氧四氢醛固酮和四氢醛固酮排泄量的总和显示出比单独的四氢醛固酮值具有更好的诊断价值。
