低尿硒浓度与新冠肺炎住院患者的非甲状腺疾病综合征有关。
Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.
作者信息
Anunciação Sara Moreira, Campos Renata de Oliveira, Beltrão Fabyan Esberard de Lima, Morais Déborah Araújo, de Wellington Sousa Tavares, Barbosa Fernando, Cassemiro Jéssica Fernanda, Rende Pedro Resende Ferreira, Hecht Fabio, Ramos Helton Estrela
机构信息
Departamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.
Programa de Pós-graduação em Processos Interativos de Órgãos e Sistemas, Instituto de Ciências e Saúde, Universidade Federal da Bahia, Salvador, BA, Brasil.
出版信息
Arch Endocrinol Metab. 2025 Jun 18;69(3):e240113. doi: 10.20945/2359-4292-2024-0113.
OBJECTIVE
This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19.
SUBJECTS AND METHODS
A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.
RESULTS
NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).
CONCLUSION
The association between low USC and NTIS was evident in this cohort.
目的
本研究旨在评估住院的成年新冠肺炎患者的尿硒浓度（USC）及其与非甲状腺疾病综合征（NTIS）和炎症标志物的相关性。
对象与方法
进行了一项前瞻性研究，以调查2020年6月至8月期间因新冠肺炎住院的成年患者的尿硒（Se）浓度。在并发症出现前，即在发病后的头48小时内采集尿液和血清样本。根据USC将121例患者分为三个三分位数组：（i）USC<25μg/L（），（ii）USC 25-39μg/L（），以及（iii）USC>39μg/L（）。采用电感耦合等离子体质谱法（ICP-MS）测量尿硒浓度。NTIS的定义为游离三碘甲状腺原氨酸低于2.3 pg/L，同时伴有低或正常的促甲状腺激素水平。
结果
NTIS的患病率较低（5.7%），且与USC最低的患者显著相关（n = 6，p = 0.008）。甲状腺炎是最常见的甲状腺并发症（23.9%）；然而，与USC无显著相关性（p>0.05）。
结论
在该队列中，低USC与NTIS之间的关联明显。
Zotero 插件