Wang Min, Xu Wenjia, Ding Yucui, Liu Xinyu, Fu Jianlong, Zhang Peng
School of Pharmacy, KeyLaboratory of Molecular Pharmacology and Drug Evaluation (Yantai University),Ministry of Education, Collaborative Innovation Center of Advanced DrugDelivery System and Biotech Drugs in Universities of Shandong, YantaiUniversity, Yantai 264005, PR China.
School of Pharmacy, KeyLaboratory of Molecular Pharmacology and Drug Evaluation (Yantai University),Ministry of Education, Collaborative Innovation Center of Advanced DrugDelivery System and Biotech Drugs in Universities of Shandong, YantaiUniversity, Yantai 264005, PR China.
Colloids Surf B Biointerfaces. 2025 Jun 16;254:114874. doi: 10.1016/j.colsurfb.2025.114874.
Nanozymes, which are artificially synthesized nanomaterials exhibiting enzyme-like activity, have garnered significant attention in recent years due to their potential as viable substitutes for natural enzymes. They demonstrate similar enzymatic kinetic properties comparable to natural enzymes and offer several advantages, including enhanced stability, cost-effective storage and preparation, reusability, and scalability. These advantages make nanozymes particularly opportunities for various applications. Notably, nanozymes can effectively regulate reactive oxygen species (ROS), thereby helping to maintain dynamic redox equilibrium within biological systems, making those nanozymes suitable for ROS-related diseases treatment, such as inflammation, neurodegenerative disorders, and cardiovascular diseases. On the other side, some nanozymes can be employed to target and eliminate tumor cells or pathogens through ROS generation, thus presenting opportunities for such disease treatment. Recent achievements in the development of nanozymes within the pharmaceutical field have significantly expanded their potential for biomedical applications. This review provides a brief overview of the classification of nanozymes, enzyme-like activity and catalytic mechanisms, and applications in disease treatment. Additionally, the challenges and future prospects of nanozymes in the biological field are also discussed. This review aims to serve as a valuable resource for researchers across multiple biomedical fields, offering insights into the design and application of nanozymes in biomedical applications.
纳米酶是一类人工合成的具有类酶活性的纳米材料，近年来因其作为天然酶的可行替代品的潜力而备受关注。它们表现出与天然酶相似的酶促动力学特性，并具有多种优势，包括增强的稳定性、经济高效的储存和制备、可重复使用性以及可扩展性。这些优势使纳米酶在各种应用中具有独特的机遇。值得注意的是，纳米酶可以有效调节活性氧（ROS），从而有助于维持生物系统内的动态氧化还原平衡，使这些纳米酶适用于与ROS相关的疾病治疗，如炎症、神经退行性疾病和心血管疾病。另一方面，一些纳米酶可通过产生ROS来靶向和消除肿瘤细胞或病原体，从而为这类疾病的治疗提供了机会。纳米酶在制药领域的最新进展显著扩展了其在生物医学应用中的潜力。本文综述简要概述了纳米酶的分类、类酶活性和催化机制以及在疾病治疗中的应用。此外，还讨论了纳米酶在生物领域面临的挑战和未来前景。本综述旨在为多个生物医学领域的研究人员提供有价值的参考，深入了解纳米酶在生物医学应用中的设计和应用。
