Agliani Gianfilippo, Visser Imke, Marshall Eleanor M, Giglia Giuseppe, de Bruin Erwin, Verstappen Ruben, van Mastrigt Tjomme, Chandler Felicity, Sikkema Reina, van der Jeugd Henk, Koopmans Marion P G, Gröne Andrea, Rockx Barry, van den Brand Judith M A
Division of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Npj Viruses. 2025 Jun 20;3(1):51. doi: 10.1038/s44298-025-00133-w.
Usutu virus (USUV) is a zoonotic arbovirus causing disease in wild birds and humans. Eurasian blackbirds (Turdus merula) are highly susceptible to infection, developing severe lesions with high mortality rates during outbreaks. The pathogenesis and clinical course of the acute disease in birds are not known. Therefore, six blackbirds were infected with two USUV lineages (Africa 3 and Europe 3). The blackbirds were monitored for clinical signs of disease and activity levels and were sampled for virus detection. All infected blackbirds showed severe disease after 4 to 7 days, with no significant differences between the lineages. Reaching a humane endpoint, the blackbirds were euthanized, and tissue samples were collected for histopathology and virology. At histopathology, lesions were seen in the main target organs with the associated presence of infectious virus and viral antigen. In conclusion, blackbirds can be infected experimentally with USUV and show similar disease as seen in natural infection.
乌苏图病毒（USUV）是一种人畜共患虫媒病毒，可导致野生鸟类和人类患病。欧亚黑鹂（乌鸫）对感染高度易感，在疫情爆发期间会出现严重病变且死亡率很高。鸟类急性疾病的发病机制和临床过程尚不清楚。因此，用两种乌苏图病毒谱系（非洲3型和欧洲3型）感染了六只黑鹂。对黑鹂进行疾病临床症状和活动水平监测，并采集样本进行病毒检测。所有受感染的黑鹂在4至7天后均表现出严重疾病，不同谱系之间无显著差异。达到人道终点后，对黑鹂实施安乐死，并采集组织样本进行组织病理学和病毒学检查。在组织病理学检查中，在主要靶器官中发现了病变，并伴有传染性病毒和病毒抗原。总之，黑鹂可通过实验感染乌苏图病毒，并表现出与自然感染相似的疾病症状。
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