Chaudhari Abhijit J, Abdelhafez Yasser G, Nardo Lorenzo, Raychaudhuri Siba P
Department of Radiology, University of California Davis, USA.
Department of Radiology, University of California Davis, USA; Nuclear Medicine Unit, South Egypt Cancer Institute, Assiut University, Egypt.
Curr Opin Immunol. 2025 Jun 19;95:102587. doi: 10.1016/j.coi.2025.102587.
Psoriatic arthritis (PsA) is a systemic, immune-mediated disorder characterized by inflammation across peripheral and axial joints, entheses, skin, and nails. Given this heterogeneous manifestation, PsA presents unique challenges in clinical diagnosis and management. Conventional imaging, limited to localized, anatomical assessments, often fails to capture the full spectrum of PsA's systemic inflammatory burden, particularly subclinical disease. This review explores the emerging role of total-body positron emission tomography (TB-PET), offering a comprehensive assessment of molecular and metabolic processes across all affected tissues of the body in a single, short, low-dose scan. With PET radiotracers targeting glucose metabolism, T-cell trafficking, and macrophage activation, TB-PET may serve as a gateway to assess the spectrum and degree of inflammation in all the pathologic domains underlying PsA. Ultimately, by bridging molecular imaging with immunology and observable phenotypic features, TB-PET may open new avenues for understanding the pathophysiology of PsA, impacting both research paradigms and clinical strategies.
银屑病关节炎（PsA）是一种全身性、免疫介导的疾病，其特征为外周和中轴关节、附着点、皮肤及指甲出现炎症。鉴于这种异质性表现，PsA在临床诊断和管理方面存在独特挑战。传统成像局限于局部解剖评估，往往无法全面捕捉PsA的全身性炎症负担，尤其是亚临床疾病。本综述探讨了全身正电子发射断层扫描（TB-PET）的新兴作用，它能在一次简短的低剂量扫描中对身体所有受影响组织的分子和代谢过程进行全面评估。通过PET放射性示踪剂靶向葡萄糖代谢、T细胞转运和巨噬细胞活化，TB-PET可作为评估PsA潜在所有病理领域炎症范围和程度的途径。最终，通过将分子成像与免疫学及可观察到的表型特征相联系，TB-PET可能为理解PsA的病理生理学开辟新途径，对研究范式和临床策略均产生影响。
