Mao Shihua, Liu Zengzhe, Yu Wenli, Zhang Wenzhe, Lin Pingan, Wang Shuaibing, Yang Jintao, Yang Guoli
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, PR China.
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, PR China.
Acta Biomater. 2025 Jun 20. doi: 10.1016/j.actbio.2025.06.036.
Sprayable hydrogels present an effective strategy for treating diabetic wounds, offering ease of application and good conformity to irregularly shaped wound sites. Nonetheless, their practical use remains significantly restricted by insufficient mechanical robustness and limited multifunctionality. Therefore, developing an approach to design sprayable hydrogel that simultaneously enhances mechanical strength, broadens functional capabilities, and ensures optimal wound adaptability is critically needed. In this work, an innovative approach integrating spatiotemporal self-strengthening and sprayability is proposed for the development of hydrogel-based wound dressings. This functionality is achieved through the synergy of rapid amidation and a gradual ring-opening reaction, equipping the hydrogels with both good wound adaptability and superior mechanical stability. The incorporation of polydopamine nanoparticles (PDA NPs) enables the creation of multifunctional therapeutic hydrogels specifically designed for chronic diabetic wound treatment. The hydrogel can be effortlessly sprayed onto wounds, progressively enhance their mechanical properties, and exhibit a combination of potent antibacterial activity, efficient reactive oxygen species (ROS) scavenging, strong bioadhesion, and outstanding biocompatibility, ultimately accelerating the diabetic wound healing process. We believe that sprayable hydrogels with these advanced properties will provide valuable insights into hydrogel-based wound dressings and expand the biomedical applications of bioinspired hydrogels. STATEMENT OF SIGNIFICANCE: Sprayable hydrogels present an effective strategy for treating diabetic wounds, offering ease of application and good conformity to irregularly shaped wound sites. Nonetheless, their practical use remains significantly restricted by insufficient mechanical robustness and limited multifunctionality. Herein, an approach integrating spatiotemporal self-strengthening and sprayability is proposed for the development of hydrogel-based wound dressings. Furthermore, we have developed sprayable hydrogel dressings with spatiotemporal self-strengthening, antibacterial and anti-inflammatory properties, consisting of double-network hydrogel and polydopamine nanoparticles (PDA NPs) as a multitargeted therapeutic system for chronic diabetic wound healing. We believe that this sprayable hydrogels will provide valuable insights into hydrogel-based wound dressings and expand the biomedical applications.
可喷涂水凝胶为治疗糖尿病伤口提供了一种有效的策略，具有易于应用且能很好地贴合不规则形状伤口部位的特点。然而，其实际应用仍因机械强度不足和多功能性有限而受到显著限制。因此，迫切需要开发一种设计可喷涂水凝胶的方法，使其同时增强机械强度、拓宽功能能力并确保最佳的伤口适应性。在这项工作中，提出了一种将时空自增强和可喷涂性相结合的创新方法来开发基于水凝胶的伤口敷料。这种功能通过快速酰胺化和逐步开环反应的协同作用来实现，使水凝胶既具有良好的伤口适应性又具有优异的机械稳定性。聚多巴胺纳米颗粒（PDA NPs）的加入使得能够创建专门用于慢性糖尿病伤口治疗的多功能治疗性水凝胶。这种水凝胶可以轻松地喷涂到伤口上，逐步增强其机械性能，并表现出强大的抗菌活性、高效的活性氧（ROS）清除能力、强生物粘附性和出色的生物相容性，最终加速糖尿病伤口愈合过程。我们相信，具有这些先进特性的可喷涂水凝胶将为基于水凝胶的伤口敷料提供有价值的见解，并扩展仿生水凝胶的生物医学应用。
可喷涂水凝胶为治疗糖尿病伤口提供了一种有效的策略，具有易于应用且能很好地贴合不规则形状伤口部位的特点。然而，其实际应用仍因机械强度不足和多功能性有限而受到显著限制。在此，提出了一种将时空自增强和可喷涂性相结合的方法来开发基于水凝胶的伤口敷料。此外，我们开发了具有时空自增强、抗菌和抗炎特性的可喷涂水凝胶敷料，其由双网络水凝胶和聚多巴胺纳米颗粒（PDA NPs）组成，作为用于慢性糖尿病伤口愈合的多靶点治疗系统。我们相信这种可喷涂水凝胶将为基于水凝胶的伤口敷料提供有价值的见解，并扩展生物医学应用。
