Hu Ye, Shao Li-Na, Zheng Jia, Zhang Xin-Miao, Song Ying-Xiang, Xing Yu-Bo
Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China.
Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China.
World J Diabetes. 2025 Jun 15;16(6):105558. doi: 10.4239/wjd.v16.i6.105558.
Young-onset type 2 diabetes mellitus (T2DM) is associated with adverse health outcomes and increased mortality. Vitamin D (VitD) deficiency is likewise linked to various adverse health outcomes and is significantly associated with lipid metabolism in patients with T2DM. However, little is known regarding the mechanisms of interaction between VitD and apolipoprotein A1 (apoA1) in young-onset T2DM.
To evaluate the relationship between VitD and apoA1 levels in patients with young-onset T2DM.
This cross-sectional study was conducted at Zhejiang Provincial People's Hospital between January 2019 and December 2023. A total of 642 patients with T2DM who aged 18-40 years were included and matched with 642 individuals without diabetes (controls) based on age and sex. No specific intervention was applied, and data were collected from medical records and laboratory tests. The relationship between VitD and apoA1 levels was examined using Spearman's correlation and logistic regression models.
We found that VitD levels were significantly lower in patients with T2DM compared to controls (15.9 ng/mL 17.4 ng/mL, < 0.001), with a notable positive correlation between VitD deficiency and reduced apoA1 levels. Multifactor logistic regression analysis identified that severe VitD deficiency was an independent risk factor for apoA1 in young-onset T2DM patients (odds ratio = 3.43, 95% confidence interval: 1.16-10.20, = 1.23, = 0.026).
Our findings reveal an association between VitD and apoA1 in young-onset T2DM, suggesting that VitD may play a crucial role in metabolic regulation and cardiovascular risk management.
青年起病的2型糖尿病（T2DM）与不良健康结局及死亡率增加相关。维生素D（VitD）缺乏同样与各种不良健康结局有关，且与T2DM患者的脂质代谢显著相关。然而，关于青年起病的T2DM中VitD与载脂蛋白A1（apoA1）之间的相互作用机制知之甚少。
评估青年起病的T2DM患者中VitD与apoA1水平之间的关系。
本横断面研究于2019年1月至2023年12月在浙江省人民医院进行。共纳入642例年龄在18 - 40岁的T2DM患者，并根据年龄和性别与642例无糖尿病个体（对照组）进行匹配。未进行特定干预，数据从病历和实验室检查中收集。使用Spearman相关性分析和逻辑回归模型检验VitD与apoA1水平之间的关系。
我们发现，与对照组相比，T2DM患者的VitD水平显著降低（15.9 ng/mL对17.4 ng/mL，P < 0.001），VitD缺乏与apoA1水平降低之间存在显著正相关。多因素逻辑回归分析确定，严重VitD缺乏是青年起病的T2DM患者apoA1的独立危险因素（比值比 = 3.43，95%置信区间：1.16 - 10.20，P = 1.23，P = 0.026）。
我们的研究结果揭示了青年起病的T2DM中VitD与apoA1之间的关联，表明VitD可能在代谢调节和心血管风险管理中起关键作用。
