Dierl Mathias, Chofor Ndimofor, Röser Arnd, Bert Christoph, Schönfeld Andreas A
Klinikum Bayreuth GmbH, Department for Medical Physics, Bayreuth, Germany; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.
Sun Nuclear, A Mirion Medical Company, Research and Development, Melbourne, USA.
Z Med Phys. 2025 Jun 24. doi: 10.1016/j.zemedi.2025.06.001.
This study presents a novel approach to measure beam-on/off latency of a surface-guided radiotherapy (SGRT) system by employing a setup with a commercial diode detector array to simultaneously capture motion profiles and monitor real-time radiation delivery on a single timestamp, without the need to synchronize different measurements devices.
Beam-on/off latencies were assessed for an AlignRT SGRT system integrated with an Elekta Versa HD and a Varian TrueBeam linear accelerator (linac). The SGRT system triggered the beam by tracking a commercial modular phantom setup comprising of an anthropomorphic head add-on surrogate and a centrally located diode detector array, with the setup mounted on a Dynamic Motion Platform (DMP). Leveraging the diode array's high sampling frequency of 50 ms, motion was simultaneously tracked by mapping the dose distribution's center of mass (CoM) to the radiation delivery timeline during the delivery of a 2×2 cm2 static field. The region of interest (ROI) for CoM calculation was confined to dose levels exceeding a 10% threshold. Latencies were evaluated for 6 MV flattened (FF) and flattening filter-free (FFF) beams at various dose rates (DR) using three DMP motion patterns (sinusoidal, sharkfin, and sawtooth). Amplitude-based gating was implemented at the SGRT system with a 5 mm position tolerance.
For the Versa HD, beam-on latency averaged 1650 ± 110 ms, remaining stable for DRs of 400-1200 MU/min for the 6 MV FFF beam. For the 6 MV FF beam, latency increased exponentially to approximately 2000 ms when the DR dropped from 200 to 50 MU/min. Beam-off latency averaged 230 ± 90 ms and was independent of DR for both 6 MV and 6 MV FFF beams. For the TrueBeam linac, beam-on latency averaged 280 ± 90 ms, showing no DR dependence in either beam configuration, while beam-off latency averaged 360 ± 90 ms, slightly shorter for 6 MV FFF compared to 6 MV FF.
The CoM method has been effectively implemented to quantify beam-on/off latencies by integrating SGRT-based motion tracking with real-time radiation dose measurements from a diode detector array, all synchronized to a single timestamp. The results revealed latency variations across different linac vendors and underscored the influence of dose rate and beam energy. With this approach, beam-on/off latencies can be efficiently assessed, providing crucial guidance for defining target volume margins, enhancing both precision and safety in high-dose stereotactic radiosurgery (SRS).
本研究提出了一种新方法,通过使用配备商业二极管探测器阵列的装置来测量表面引导放射治疗(SGRT)系统的射束开启/关闭延迟,该装置能够在单个时间戳上同时捕获运动轮廓并监测实时放射治疗输送情况,无需同步不同的测量设备。
对与医科达Versa HD和瓦里安TrueBeam直线加速器(直线加速器)集成的AlignRT SGRT系统进行射束开启/关闭延迟评估。SGRT系统通过跟踪一个商业模块化体模装置来触发射束,该装置包括一个拟人化头部附加替代物和一个位于中心的二极管探测器阵列,该装置安装在动态运动平台(DMP)上。利用二极管阵列50毫秒的高采样频率,在2×2平方厘米静态射野照射期间,通过将剂量分布的质心(CoM)映射到放射治疗输送时间线来同时跟踪运动。用于CoM计算的感兴趣区域(ROI)限于超过10%阈值的剂量水平。使用三种DMP运动模式(正弦、鱼鳍和锯齿),在不同剂量率(DR)下对6兆伏扁平(FF)和无均整器(FFF)射束的延迟进行评估。在SGRT系统上实施基于幅度的门控,位置容差为5毫米。
对于Versa HD,射束开启延迟平均为1650±110毫秒,对于6兆伏FFF射束,在400 - 1200 MU/分钟的剂量率下保持稳定。对于6兆伏FF射束,当剂量率从200降至50 MU/分钟时,延迟呈指数增加至约2000毫秒。射束关闭延迟平均为230±90毫秒,对于6兆伏和6兆伏FFF射束均与剂量率无关。对于TrueBeam直线加速器,射束开启延迟平均为280±90毫秒,在两种射束配置下均未显示出对剂量率的依赖性,而射束关闭延迟平均为360±90毫秒,6兆伏FFF射束比6兆伏FF射束略短。
通过将基于SGRT的运动跟踪与来自二极管探测器阵列的实时放射剂量测量相结合,并将所有测量同步到单个时间戳,CoM方法已有效地用于量化射束开启/关闭延迟。结果揭示了不同直线加速器供应商之间的延迟差异,并强调了剂量率和射束能量的影响。通过这种方法,可以有效地评估射束开启/关闭延迟,为定义靶区边缘提供关键指导,提高高剂量立体定向放射治疗(SRS)的精度和安全性。