Tokuchi Keiko, Yanagi Teruki, Maeda Takuya, Nakazato Shinichi, Miyamoto Kodai, Tomaru Utano, Anan Takashi, Ujiie Hideyuki
Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Case Rep Dermatol. 2025 Apr 10;17(1):240-245. doi: 10.1159/000545712. eCollection 2025 Jan-Dec.
Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma.
A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes.
TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy.
管状大汗腺腺瘤（TAA）是一种罕见的汗腺肿瘤，通常表现为头皮上边界清晰、呈红色至棕色的结节。一般来说，TAA被认为是良性肿瘤；然而，将TAA与转移性或原发性癌区分开来可能具有挑战性。
一名90多岁的女性，其右耳后出现淡红色结节3年。组织学检查显示真皮内有几个包含两层结构的管状结构，呈现断头分泌现象。在病变周边，鳞状肿瘤细胞形成巢状结构，部分鳞状肿瘤细胞表现为多核。基于组织病理学、免疫组织化学和分子生物学检查结果，该肿瘤被诊断为具有未明确恶性改变的TAA。
TAA是一种罕见的汗腺肿瘤。虽然TAA通常为良性，但它可能具有侵袭性特征，因此进行全面的病理评估对于排除恶性肿瘤至关重要。
