Gonzalez-Ferrer Shekina, Yanagimoto-Ogawa Lauren, Zhuo Ran, Matysiak Match Colette J, Dayo Ashley, Kang Yuna, Yang Shangxin
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
IDCases. 2025 Jun 10;41:e02284. doi: 10.1016/j.idcr.2025.e02284. eCollection 2025.
We report a rare case of mycetoma after renal transplant in a patient with distant exposure to mangroves during disaster relief efforts in the Caribbean. Histopathology and fungal culture from the skin biopsy revealed findings consistent with chronic mycetoma caused by a dematiaceous mold. Next Generation Sequencing (NGS) identified the organism as closely related to , a fungus originally isolated from mangroves. This case highlights the emerging threat posed by environmental dematiaceous fungi as obscure opportunistic pathogens in the setting of natural disasters, especially for immunocompromised patients, and the pivotal diagnostic role of NGS in invasive fungal infections.
我们报告了一例肾移植后发生足菌肿的罕见病例，该患者在加勒比地区救灾期间曾远距离接触红树林。皮肤活检的组织病理学和真菌培养结果显示， findings与由暗色霉菌引起的慢性足菌肿一致。下一代测序（NGS）确定该病原体与 originally isolated from mangroves的一种真菌密切相关。该病例凸显了环境暗色真菌作为自然灾害背景下隐匿的机会性病原体所带来的新威胁，尤其是对免疫功能低下的患者，以及NGS在侵袭性真菌感染诊断中的关键作用。 （注：原文中“findings”和“originally isolated from mangroves”处表述不完整，可能影响准确理解）
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