Li Song, Lu Li, Xiong Yuan, Xiao Jun
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China.
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China.
Burns Trauma. 2025 Feb 10;13:tkaf015. doi: 10.1093/burnst/tkaf015. eCollection 2025.
Tissue regeneration is essential for repairing and restoring damaged tissues, which has significant implications for clinical outcomes. Understanding the cellular mechanisms and the role of the immune system in this process provides a basis for improved regenerative techniques. The emergence of nanomedicine has advanced this field by introducing nanoscale technology that offer precise control over therapeutic delivery and cellular interactions. By modulating immune responses, various immunotherapeutic approaches, including cytokine therapy and immune checkpoint inhibitors, can establish an optimal environment for tissue repair. This review summarizes recent findings and applications of nanomedicine-based immunotherapy in tissue regeneration. It highlights the properties and advantages of nanomedicine in immunotherapy, discusses recent progress in using nanocomposite biomaterials for tissue engineering, and addresses the challenges and future directions in this evolving field. This review aims to emphasize the promising potential of nanomedicine-based immunotherapy in tissue engineering, thereby contributing to the functional design and strategic development of next-generation nanomedicine for regenerative medicine.
组织再生对于修复和恢复受损组织至关重要，这对临床结果具有重要意义。了解细胞机制以及免疫系统在此过程中的作用为改进再生技术提供了基础。纳米医学的出现通过引入纳米级技术推动了该领域的发展，这些技术能够对治疗递送和细胞相互作用进行精确控制。通过调节免疫反应，包括细胞因子疗法和免疫检查点抑制剂在内的各种免疫治疗方法可以为组织修复建立最佳环境。本综述总结了基于纳米医学的免疫疗法在组织再生中的最新发现和应用。它突出了纳米医学在免疫治疗中的特性和优势，讨论了使用纳米复合生物材料进行组织工程的最新进展，并探讨了这一不断发展的领域中的挑战和未来方向。本综述旨在强调基于纳米医学的免疫疗法在组织工程中的广阔前景，从而为再生医学下一代纳米医学的功能设计和战略发展做出贡献。
