Wang Hongli, Chen Min, Wang Tengyue, Cai Wenyu, Li Xuanlin, Huang Lin, Wang Mingzhu
Innovative Research Center for Basic Medicine on Autoimmune Diseases, Ministry of Education, Hangzhou, Zhejiang, China.
Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Front Immunol. 2025 Jun 12;16:1539997. doi: 10.3389/fimmu.2025.1539997. eCollection 2025.
Atopic dermatitis (AD) is a common recurrent chronic inflammatory skin disease, and there is increasing evidence of a possible association between AD and autoimmune diseases.
This study aimed to summarize existing epidemiological studies on the association between AD and autoimmune diseases and to perform a meta-analysis of combinable results.
We conducted a thorough search for cohort studies, case-control studies and cross-sectional studies across the PubMed, Cochrane Library, and Embase databases, from their inception to May 24, 2024, using medical subject headings and relevant keywords. All data were meticulously analyzed using Stata statistical software version 17.0. The protocol was registered on PROSPERO (CRD42024547282).
A total of 26 cohort studies, comprising 1,629,723 patients with atopic dermatitis and 15,106,889 control subjects, were included in this meta-analysis. These studies were published between 2014 and 2024 and included 19 cohort studies, 2 case-control studies, and 5 cross-sectional studies. The current study demonstrated a significant association of atopic dermatitis with autoimmune diseases[HR 1.49, 95% CI (1.31-1.70); 0.001], including celiac disease, systemic lupus erythematosus, Sjogren's syndrome, ankylosing spondylitis, alopecia areata, rheumatoid arthritis, vitiligo, thyroid dysfunction, ulcerative colitis.
The results of our study indicate a clear association between atopic dermatitis and autoimmune diseases, both in adults and children. Additionally, women were more likely to have autoimmune disease complications than men. However, due to the limited number of participants in our study, further research is needed to thoroughly investigate the relationship.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024547282.
特应性皮炎（AD）是一种常见的复发性慢性炎症性皮肤病，越来越多的证据表明AD与自身免疫性疾病之间可能存在关联。
本研究旨在总结现有的关于AD与自身免疫性疾病关联的流行病学研究，并对可合并的结果进行荟萃分析。
我们使用医学主题词和相关关键词，在PubMed、Cochrane图书馆和Embase数据库中，从建库至2024年5月24日，全面检索队列研究、病例对照研究和横断面研究。所有数据均使用Stata统计软件17.0进行细致分析。该方案已在PROSPERO（CRD42024547282）上注册。
本荟萃分析共纳入26项队列研究，包括1629723例特应性皮炎患者和15106889例对照。这些研究发表于2014年至2024年之间，包括19项队列研究、2项病例对照研究和5项横断面研究。当前研究表明，特应性皮炎与自身免疫性疾病存在显著关联[风险比1.49，95%置信区间（1.31 - 1.70）；P = 0.001]，包括乳糜泻、系统性红斑狼疮、干燥综合征、强直性脊柱炎、斑秃、类风湿关节炎、白癜风、甲状腺功能障碍、溃疡性结肠炎。
我们的研究结果表明，特应性皮炎与自身免疫性疾病在成人和儿童中均存在明确关联。此外，女性比男性更易出现自身免疫性疾病并发症。然而，由于本研究参与者数量有限，需要进一步研究以全面探究两者关系。
