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经导管治疗二尖瓣心内膜炎合并严重主动脉瓣狭窄和关闭不全患者

Transcatheter Treatment of Patient With Mitral Valve Endocarditis and Severe Aortic Stenosis and Insufficiency.

作者信息

Rajagopal Dhiren R, Jayanthi Rishab, Bolivar Aldana Jennifer J, Stewart James P, Sayegh Hassan S, Flueckiger Peter B, Mobasseri Sara, Helmers Mark R, Thourani Vinod H, Yadav Pradeep K

机构信息

Marcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA; Georgia Institute of Technology, Atlanta, Georgia, USA.

Marcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.

出版信息

JACC Case Rep. 2025 Aug 20;30(24):104186. doi: 10.1016/j.jaccas.2025.104186. Epub 2025 Jun 27.

Abstract

BACKGROUND

Patients in cardiogenic shock secondary to endocarditis and multivalvular heart disease have a high surgical risk. Transcatheter valve aspiration followed by transcatheter valve intervention might be a strategy to salvage carefully selected patients.

CASE SUMMARY

A 63-year-old woman with subaortic membrane and severe aortic stenosis/regurgitation was scheduled for membrane resection, aortic root enlargement, and aortic valve replacement. Two weeks before operation, she developed mitral valve endocarditis. Because of cardiogenic shock, she was placed on venoarterial extracorporeal membrane oxygenation with a left atrial vent. Transcatheter aspiration of mitral vegetation resulted in minimal residual valve pathology with culture clearance; the patient received transcatheter aortic valve replacement and was discharged to a rehabilitation facility.

DISCUSSION

Surgery in patients with multivalvular disease with endocarditis and cardiogenic shock can be very high risk. Transcatheter aspiration of endocarditis and treatment of valvular disease might be an alternative to high-risk surgical therapy.

TAKE-HOME MESSAGES: Surgical treatment has been the only available option for patients with endocarditis and multivalvular disease. In these patients at very high operative risk and with appropriate valvular anatomy, transcatheter aspiration of endocarditis followed by transcatheter therapy of multiple valvular lesions can be feasible alternative.

摘要

背景

心内膜炎和多瓣膜心脏病继发的心源性休克患者手术风险高。经导管瓣膜抽吸后行经导管瓣膜介入治疗可能是挽救精心挑选患者的一种策略。

病例摘要

一名63岁女性,患有主动脉瓣下隔膜及严重主动脉瓣狭窄/反流,计划行隔膜切除术、主动脉根部扩大术及主动脉瓣置换术。术前两周,她发生了二尖瓣心内膜炎。因心源性休克,她接受了带有左心房引流管的静脉-动脉体外膜肺氧合支持。经导管抽吸二尖瓣赘生物后,瓣膜残留病变极小且培养转阴;患者接受了经导管主动脉瓣置换术,随后出院至康复机构。

讨论

多瓣膜病合并心内膜炎及心源性休克患者的手术风险可能非常高。经导管抽吸心内膜炎及治疗瓣膜疾病可能是高风险手术治疗的替代方案。

要点

手术治疗一直是心内膜炎和多瓣膜病患者唯一可行的选择。对于这些手术风险极高且瓣膜解剖结构合适的患者,经导管抽吸心内膜炎后行多瓣膜病变的经导管治疗可能是可行的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd6/12373495/a992f6ad21b6/ga1.jpg

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