Hashimoto Kazuhiko, Nishimura Shunji, Goto Koji
Department of Orthopedic Surgery, Kindai University Hospital, Ohnohigashi, Japan
Department of Orthopedic Surgery, Kindai University Hospital, Ohnohigashi, Japan.
In Vivo. 2025 Jul-Aug;39(4):2436-2440. doi: 10.21873/invivo.14043.
BACKGROUND/AIM: Giant cell tumor of the bone (GCTB) is a locally-aggressive, benign tumor that typically affects young adults between 20 and 40 years old.
A 15-year-old female presented to a primary care physician with pain in the lateral aspect of the left knee and was referred to our department with a suspected bone tumor owing to radiographic findings of osteolysis of the proximal fibula. Computed tomography indicated osteolysis of the proximal fibula, and the bone cortex was thin and partially irregular. Magnetic resonance imaging indicated a mass in the same area, with hyperintense changes in both T1- and T2-weighted images. No biopsy was performed; however, bone tumor curettage and artificial bone grafting were performed. The final pathological examination indicated osteoclastic, multinucleated giant cells. No malignant findings were observed, and the patient was diagnosed with GCTB. No recurrence was observed one year after surgery.
This case highlights the occurrence of GCTB in a young patient at an uncommon location. Oncologic surgeons should consider GCTB as a differential diagnosis when an image shows translucency of the proximal fibula, even if the patient is younger than the usual age of onset.
背景/目的：骨巨细胞瘤（GCTB）是一种具有局部侵袭性的良性肿瘤，通常影响20至40岁的年轻人。
一名15岁女性因左膝外侧疼痛就诊于初级保健医生处，由于近端腓骨骨质溶解的影像学表现，疑似骨肿瘤而被转诊至我科。计算机断层扫描显示近端腓骨骨质溶解，骨皮质变薄且部分不规则。磁共振成像显示同一区域有肿块，在T1加权和T2加权图像上均有高信号改变。未进行活检；然而，进行了骨肿瘤刮除术和人工骨移植。最终病理检查显示有破骨细胞、多核巨细胞。未观察到恶性表现，患者被诊断为GCTB。术后一年未观察到复发。
该病例突出了GCTB在年轻患者中于不常见部位的发生情况。当影像学显示近端腓骨透亮时，肿瘤外科医生应将GCTB作为鉴别诊断，即使患者年龄低于通常发病年龄。
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