Filion Kristian B, Zolotarova Tetiana, Hébert-Losier Andréa, Windle Sarah B, Reynier Pauline, Greenspoon Todd, Brandys Tim, Fülöp Tamàs, Nguyen Thang, Elkouri Stéphane, Wilderman Igor, Bertrand Olivier F, Bostwick Joanna Alexis, Lacasse Yves, Pakhale Smita, Eisenberg Mark J
Departments of Medicine and of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada; Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.
JACC Adv. 2025 Jun;4(6 Pt 2):101833. doi: 10.1016/j.jacadv.2025.101833.
The current evidence regarding the long-term efficacy of electronic cigarettes (e-cigarettes) for smoking cessation is unclear.
The purpose of this study was to assess the efficacy, safety, and tolerability of nicotine and non-nicotine e-cigarettes for smoking cessation in the general population.
We randomized 376 adults who smoked ≥10 cigarettes/day and were motivated to quit at 17 Canadian sites to 12 weeks of nicotine (15 mg/mL) e-cigarettes (n = 128), non-nicotine e-cigarettes (n = 127), or no e-cigarettes (n = 121). All groups received individual counseling. The primary endpoint was point prevalence abstinence (7-day recall, biochemically validated using expired carbon monoxide) at 12 weeks. The 52-week follow-up results are reported here.
Participants (mean age 52 ± 13 years; 47% female) smoked a mean of 21 ± 11 cigarettes/day at baseline. Compared to individual counseling alone, participants randomized to nicotine e-cigarettes plus counseling had higher rates of point prevalence (23.6% vs 9.9%; difference: 13.7%; 95% CI: 4.6%-22.8%) and continuous abstinence (3.1% vs 0.0%; difference: 3.1%; 95% CI: 0.1%-6.2%) and greater reductions in the number of cigarettes smoked (-9.5 ± 10.5 vs -5.6 ± 9.5; difference: -3.9; 95% CI: -6.5 to -1.4) at 52 weeks. Benefits were also observed among participants randomized to non-nicotine e-cigarettes plus counseling vs counseling alone. No differences in abstinence or reduction were found between nicotine and non-nicotine e-cigarettes.
Compared to individual counseling alone, short-term use of standardized nicotine and non-nicotine e-cigarettes plus counseling is efficacious at increasing smoking abstinence at 52 weeks.
目前关于电子烟用于戒烟的长期疗效的证据尚不明确。
本研究旨在评估尼古丁电子烟和无尼古丁电子烟在普通人群中戒烟的疗效、安全性和耐受性。
我们将17个加拿大研究点的376名每天吸烟≥10支且有戒烟意愿的成年人随机分为三组，分别使用尼古丁（15毫克/毫升）电子烟12周（n = 128）、无尼古丁电子烟12周（n = 127）或不使用电子烟（n = 121）。所有组均接受个体咨询。主要终点是12周时的点患病率戒断情况（7天回顾法，通过呼出一氧化碳进行生化验证）。本文报告了52周的随访结果。
参与者（平均年龄52±13岁；47%为女性）在基线时平均每天吸烟21±11支。与仅接受个体咨询相比，随机分配到尼古丁电子烟加咨询组的参与者在52周时的点患病率（23.6%对9.9%；差异：13.7%；95%置信区间：4.6%-22.8%）和持续戒断率（3.1%对0.0%；差异：3.1%；95%置信区间：0.1%-6.2%）更高，且吸烟量减少更多（-9.5±10.5对-5.6±9.5；差异：-3.9；95%置信区间：-6.5至-1.4）。在随机分配到无尼古丁电子烟加咨询组与仅接受咨询组的参与者中也观察到了益处。尼古丁电子烟和无尼古丁电子烟在戒断或吸烟量减少方面没有差异。
与仅接受个体咨询相比，短期使用标准化的尼古丁电子烟和无尼古丁电子烟加咨询在52周时能有效提高戒烟率。
