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炎症标志物正常的暴发性心肌炎

Fulminant Myocarditis With Normal Inflammatory Markers.

作者信息

Nirthanakumaran Deva, Pathan Shahab, Parikh Devang, Pathan Faraz

机构信息

Department of Cardiology, Nepean Hospital, Sydney, Australia; University of Sydney, Sydney, Australia.

Department of Cardiology, Nepean Hospital, Sydney, Australia.

出版信息

JACC Case Rep. 2025 Jun 25;30(16):103878. doi: 10.1016/j.jaccas.2025.103878.

Abstract

BACKGROUND

Fulminant myocarditis is a rare, rapidly progressive and life-threatening condition requiring early diagnosis and management.

CASE SUMMARY

We present the case of a 31-year-old man who presented with sudden onset chest pain; though his initial echocardiography was largely unremarkable, and angiography ruled out acute coronary syndrome, the patient developed worsening pain with rising high-sensitivity troponin markers. Cardiac magnetic resonance imaging revealed widespread transmural late gadolinium enhancement throughout the left ventricle, which prompted urgent transfer to a quaternary center before the patient's acute deterioration. The patient deteriorated from symptom onset to overt cardiogenic shock requiring intubation, mechanical circulatory support, and high-dose immunosuppression within 25 hours.

DISCUSSION

This case underscores the importance of multimodality imaging for rapid decision-making in diagnosing myocarditis, particularly when clinical suspicion is high despite initial nonspecific biochemical tests and echocardiography.

摘要

背景

暴发性心肌炎是一种罕见、进展迅速且危及生命的疾病,需要早期诊断和治疗。

病例摘要

我们报告一例31岁男性患者,该患者突发胸痛;尽管其初始超声心动图基本无异常,血管造影排除了急性冠状动脉综合征,但患者胸痛加重,高敏肌钙蛋白标志物升高。心脏磁共振成像显示左心室广泛透壁晚期钆增强,这促使在患者急性恶化前紧急转至四级中心。患者从症状发作到出现明显的心源性休克,在25小时内需要插管、机械循环支持和大剂量免疫抑制治疗。

讨论

该病例强调了多模态成像在心肌炎诊断中快速决策的重要性,尤其是在尽管初始生化检查和超声心动图无特异性但临床怀疑度高的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51bc/12273852/3d0c7c064a18/ga1.jpg

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