0.5ZnO@Cu5.4O纳米颗粒用于调节GSDMB的表达及肿瘤的靶向治疗。
0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor.
作者信息
Zhang Hao, Liu Guoyan
机构信息
Department of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
出版信息
Cancer Cell Int. 2025 Jun 28;25(1):238. doi: 10.1186/s12935-025-03874-z.
GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhibit GSDMB, a capability that neither ZnO nor Cu5.4O possesses. ZnO@Cu5.4O with different ratios also exhibits varying inhibitory effects. The 0.5ZnO@Cu5.4O can be cleared quickly in vivo, ensuring biocompatibility. Additionally, 0.5ZnO@Cu5.4O significantly inhibits tumor progression, offering promising avenues for clinical cancer therapy, and the development of gene-regulating nanoparticles.
GSDMB是细胞焦亡中的关键蛋白，与多种疾病密切相关。纳米材料可以靶向并调节特定途径。在此，我们报告一种简单高效的一步法来制备能够抑制GSDMB表达的多酶纳米颗粒。0.5ZnO@Cu5.4O能够抑制GSDMB，而ZnO和Cu5.4O均不具备这种能力。不同比例的ZnO@Cu5.4O也表现出不同的抑制效果。0.5ZnO@Cu5.4O在体内可快速清除，确保了生物相容性。此外，0.5ZnO@Cu5.4O显著抑制肿瘤进展，为临床癌症治疗以及基因调控纳米颗粒的开发提供了有前景的途径。
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