难治性边缘区淋巴瘤揭示了1型活化磷脂酰肌醇3激酶δ综合征（APDS1）。
Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1).
作者信息
Wonnaparhown Alex, Farley Matthew, Miller Holly, Cunningham-Rundles Charlotte, Freeman Catherine, Squire Jacqueline, Hilal Talal, Rosenthal Allison
机构信息
Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Phoenix, Ariz.
Center for Cancer and Blood Disorders, Phoenix Children's/Mayo Clinic Arizona, Phoenix, Ariz.
出版信息
J Allergy Clin Immunol Glob. 2025 May 26;4(3):100503. doi: 10.1016/j.jacig.2025.100503. eCollection 2025 Aug.
Abstract
Activated PI3K delta syndrome is a rare primary combined immunodeficiency that can present with lymphoma. Genetic testing of patients with atypical lymphoma may reveal an underlying immunodeficiency and improve clinical outcomes.
摘要
活化PI3Kδ综合征是一种罕见的原发性联合免疫缺陷病，可伴有淋巴瘤。对非典型淋巴瘤患者进行基因检测可能会揭示潜在的免疫缺陷，并改善临床结局。
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