Li Danyang, Saavedra Pedro H V
Department of Biology, Northeastern University, Boston, Massachusetts, USA.
mBio. 2025 Aug 13;16(8):e0356224. doi: 10.1128/mbio.03562-24. Epub 2025 Jul 1.
infection (CDI) is a major public health concern and the leading cause of healthcare-associated infectious enteric inflammation worldwide. Disruption of the gut microbiome predisposes to colonization, proliferation, and production of cytotoxic toxins that damage the intestinal epithelial layer. CDI treatment is challenging in part due to the emergence of antibiotic-resistant strains and the lack of efficient vaccines, predisposing individuals to recurrent CDI episodes. Consequently, there is an urgent need for the development of novel therapeutic approaches. Both innate and adaptive immune responses contribute to protection against CDI, but the cellular and molecular mechanisms underlying this process are not completely understood. In this mini review, I discuss the history and recent findings with a focus on mechanisms that drive host immunity to , with a conclusion on where the field stands and outstanding questions that remain elusive.
艰难梭菌感染（CDI）是一个重大的公共卫生问题，是全球医疗保健相关感染性肠道炎症的主要原因。肠道微生物群的破坏易引发艰难梭菌的定植、增殖以及细胞毒素的产生，这些毒素会损害肠道上皮层。CDI治疗具有挑战性，部分原因是抗生素耐药菌株的出现以及缺乏有效的疫苗，这使得个体易反复发生CDI发作。因此，迫切需要开发新的治疗方法。先天性和适应性免疫反应均有助于抵御CDI，但这一过程背后的细胞和分子机制尚未完全明确。在本综述中，我将讨论艰难梭菌感染的历史和最新研究发现，重点关注驱动宿主对艰难梭菌免疫的机制，并对该领域的现状和仍未解决的突出问题进行总结。
