Yang Hee Joo, Kim Young Jae, Na Hyoungmin, Jo Yoon-Seo, Chang Sung Eun, Eom Jin Sup, Hong Yong Sang, Lee Dae Ho, Lee Mi Woo, Lee Woo Jin, Won Chong Hyun, Lim Youngkyoung, Lee Jong Seok
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Department of Plastic surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2025 Jul 1;15(1):21196. doi: 10.1038/s41598-025-03553-z.
Previous studies suggested racial difference between young melanomas of Caucasians and non-Caucasians. This study aimed to elucidate characteristics of melanomas in young Asians. We analyzed clinical and histologic characteristics of patients under age 40 diagnosed with cutaneous melanomas including in situs. Survival and subgroup analyses were conducted. Among the 45 patients investigated, the most common anatomical sites of melanomas were lower extremities (22/45, 45.3%) and acral lentiginous type was the most common histological variety (18/45, 40%), of which 12 were subungual type. Lymph node involvement and nodular histologic type were significant prognostic factors. Age subgroup analysis revealed that clinical and histopathologic features of adolescents (15-21 years old [YO]) were distinct from those of young adults (22-39 YO), but similar to children (0-14 YO) who showed amelanotic nodules (p < 0.01) and spitzoid subtypes (p < 0.001). Pediatric melanomas (< 20 YO), showed racial differences based on sex (p < 0.01), an-atomical site (p < 0.001), histologic types (p < 0.001), and lymph node involvement at diagnosis (p < 0.047). Understanding the differences among age groups will help clinicians decide management of melanomas in young Asian patients.
以往研究表明，白种人和非白种人年轻黑色素瘤患者之间存在种族差异。本研究旨在阐明亚洲年轻人群黑色素瘤的特征。我们分析了40岁及以下诊断为包括原位黑色素瘤在内的皮肤黑色素瘤患者的临床和组织学特征，并进行了生存分析和亚组分析。在45例研究对象中，黑色素瘤最常见的解剖部位是下肢（22/45，45.3%），肢端雀斑样痣型是最常见的组织学类型（18/45，40%），其中12例为甲下型。淋巴结受累和结节状组织学类型是重要的预后因素。年龄亚组分析显示，青少年（15 - 21岁）的临床和组织病理学特征与青年成人（22 - 39岁）不同，但与表现为无黑色素结节（p < 0.01）和梭形细胞亚型（p < 0.001）的儿童（0 - 14岁）相似。儿童黑色素瘤（< 20岁）在性别（p < 0.01）、解剖部位（p < 0.001）、组织学类型（p < 0.001）以及诊断时的淋巴结受累情况（p < 0.047）方面存在种族差异。了解不同年龄组之间的差异将有助于临床医生决定对亚洲年轻黑色素瘤患者的治疗方案。
