Marcos-Prieto Pablo, Ordali Erica, Mariotti Veronica, Palumbo Sara, Vellucci Stefano, Ricciardi Emiliano, Boncinelli Leonardo, Pietrini Pietro, Pellegrini Silvia, Bilancini Ennio
IMT School for Advanced Studies Lucca, P.zza San Francesco 19, 55100, Lucca, Italy.
Department of Economics and Management, University of Firenze, Via Delle Pandette 32, 50127, Firenze, Italy.
Sci Rep. 2025 Jul 1;15(1):20641. doi: 10.1038/s41598-025-03772-4.
Genetic variants in dopaminergic and serotonergic pathways have been linked to individual differences in social behavior. In this study, we investigated the relationship between eight allelic variants within these pathways and both behavior and beliefs in 99 participants playing an online Public Goods Game (PGG) with and without punishment. Our results show that individuals with the 5-HTTLPR L/L genotype contributed less and had lower expectations of others' contributions in the absence of punishment; the 5-HTR1B-rs13212041 T/T genotype was associated with lower expectations of antisocial and spiteful punishment; the COMT-rs4680 A/A (Met/Met) genotype was linked to lower expectations of contributions in the presence of punishment. These findings suggest that specific alleles modulate both cooperative behavior and social expectations, suggesting a genetic contribution to individual variability in responses to social dilemmas.
多巴胺能和血清素能通路中的基因变异与社会行为的个体差异有关。在本研究中，我们调查了这些通路中的八个等位基因变异与99名参与者在有惩罚和无惩罚情况下玩在线公共物品博弈（PGG）时的行为和信念之间的关系。我们的结果表明，5-HTTLPR L/L基因型的个体贡献较少，且在无惩罚情况下对他人贡献的期望较低；5-HTR1B-rs13212041 T/T基因型与对反社会和恶意惩罚的较低期望相关；COMT-rs4680 A/A（Met/Met）基因型与在有惩罚情况下对贡献的较低期望有关。这些发现表明，特定等位基因调节合作行为和社会期望，提示基因对个体应对社会困境的变异性有贡献。
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