Sekido Noritoshi, Omae Kenji, Haga Nobuhiro, Kubota Yasue, Saito Motoaki, Sakakibara Ryuji, Yoshida Mikako, Mitsui Takahiko, Masumori Naoya, Takahashi Satoru
Epidemiological Survey Executive Committee, The Japanese Continence Society, Chiyoda-ku, Japan.
Department of Urology, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.
Sci Rep. 2025 Jul 1;15(1):21313. doi: 10.1038/s41598-025-06299-w.
Co-existent overactive-underactive bladder (COUB) is an area of highly unmet medical need, and epidemiological information is lacking, especially in men. Therefore, to illuminate the epidemiological characteristics of COUB in men, 3112 adult Japanese men responding to a nationwide internet survey on lower urinary tract symptoms (LUTS) were divided into COUB, overactive bladder (OAB) alone, underactive bladder (UAB) alone, and non-OAB/UAB groups based on the OAB symptom score and the International Continence Society-Working Group definition of UAB. We assessed each group's prevalence and health-related quality of life (HRQOL) and explored predictors of COUB as well as OAB and UAB using multinomial logistic regression analysis. The prevalences of COUB, OAB alone, and UAB alone were 4.3%, 9.6%, and 5.0%, respectively, and increased significantly with age. The proportions of COUB in OAB and UAB overall were 31.1% and 46.6%, respectively, but showed no significant increase with age. The proportion of participants experiencing an impact on their HRQOL was highest in the COUB group. A multinomial logistic regression analysis revealed that COUB and OAB alone shared predictive factors. The presence of COUB has a considerable impact on HRQOL and should be kept in mind when managing LUTS in men.
膀胱过度活动症与膀胱活动低下共存（COUB）是一个医疗需求远未满足的领域，且缺乏流行病学信息，尤其是在男性中。因此，为了阐明男性COUB的流行病学特征，对3112名参与全国性互联网下尿路症状（LUTS）调查的成年日本男性，根据膀胱过度活动症（OAB）症状评分和国际尿控协会工作组对膀胱活动低下（UAB）的定义，将其分为COUB组、单纯膀胱过度活动症（OAB）组、单纯膀胱活动低下（UAB）组和非OAB/UAB组。我们评估了每组的患病率和健康相关生活质量（HRQOL），并使用多项逻辑回归分析探索了COUB以及OAB和UAB的预测因素。COUB、单纯OAB和单纯UAB的患病率分别为4.3%、9.6%和5.0%，且随年龄显著增加。COUB在OAB和UAB总体中的比例分别为31.1%和46.6%，但未随年龄显著增加。COUB组中对HRQOL产生影响的参与者比例最高。多项逻辑回归分析显示，COUB和单纯OAB有共同的预测因素。COUB的存在对HRQOL有相当大的影响，在管理男性LUTS时应予以考虑。
