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原发性中枢神经系统淋巴瘤中临床疑似副肿瘤性血管炎性周围神经病:一例报告

Clinically probable paraneoplastic vasculitic peripheral neuropathy in primary central nervous system lymphoma: a case report.

作者信息

Zhang Zhuangzhuang, Ling Chen, Zhang Yingshuang, Sun Weiping, Wang Zhaoxia, Meng Lingchao

机构信息

Department of Neurology, Peking University First Hospital, Beijing, China.

Department of Neurology, Peking University Third Hospital, Beijing, China.

出版信息

BMC Neurol. 2025 Jun 24;25(1):252. doi: 10.1186/s12883-025-04285-3.

Abstract

Primary central nervous system lymphoma (PCNSL) is a malignant tumor known to cause direct mass effects and various paraneoplastic syndromes. However, paraneoplastic vasculitic peripheral neuropathy is rarely associated with PCNSL. In this case report, we describe a patient with PCNSL who presented with probable paraneoplastic vasculitic peripheral neuropathy. The patient initially experienced recurrent pain and weakness in bilateral lower limbs for two years, followed by a sudden decline in consciousness over two days. A biopsy of the right sural nerve revealed probable vasculitic peripheral neuropathy, and the diagnosis of PCNSL was confirmed through brain biopsy.

摘要

原发性中枢神经系统淋巴瘤(PCNSL)是一种已知会引起直接占位效应和各种副肿瘤综合征的恶性肿瘤。然而,副肿瘤性血管炎性周围神经病很少与PCNSL相关。在本病例报告中,我们描述了一名患有PCNSL的患者,该患者表现出可能的副肿瘤性血管炎性周围神经病。患者最初双侧下肢反复出现疼痛和无力症状达两年,随后在两天内意识突然下降。右侧腓肠神经活检显示可能为血管炎性周围神经病,通过脑活检确诊为PCNSL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fe/12210424/eb9fde3a7362/12883_2025_4285_Fig1_HTML.jpg

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