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应用于取向介质中分子分析的双相样品的空间分辨碳核磁共振光谱学。

Spatially Resolved C NMR Spectroscopy in Bimesophasic Samples Applied to Molecular Analysis in Orienting Media.

作者信息

Julien Thomas, Gouilleux Boris, Reggelin Michael, Lesot Philippe

机构信息

RMN en Milieu Orienté, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), UMR CNRS 8182, Université Paris-Saclay, UFR des Sciences d'Orsay, Orsay, France.

Clemens-Schöpf-Institut für Organische Chemie und Biochemie Technische Universität Darmstadt, Darmstadt, Germany.

出版信息

Magn Reson Chem. 2025 Sep;63(9):691-702. doi: 10.1002/mrc.70003. Epub 2025 Jul 1.

DOI:10.1002/mrc.70003
PMID:40598922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318900/
Abstract

The use of lyotropic, chiral bimesophasic systems and spatially resolved H nD NMR spectroscopy has recently been pioneered (J. Phys. Chem. Lett. 2024) as an original tool capable of providing two independent sets of anisotropic spectral data with a single NMR sample. In this work, we explore the analytical potential of spatially localized C and C-{H} 1D and 2D NMR experiments (CLIP-HSQC, T-resolved) combined with bimesophasic samples composed of polypeptide and polyacetylene chiral polymers (PBLG and L-MSP). The effectiveness of this original anisotropic approach is being explored in the context of the enantiomeric analysis of chiral molecules such as ibuprofen, as well as the configurational and 3D structural analysis of multi-stereocenter chiral compounds (case of (+)-IPC).

摘要

溶致性手性双介相体系和空间分辨的H nD NMR光谱学的应用最近已被开创（《物理化学快报》，2024年），作为一种能够用单个NMR样品提供两组独立各向异性光谱数据的原始工具。在这项工作中，我们探索了空间定位的C和C-{H} 1D和2D NMR实验（CLIP-HSQC，T分辨）与由多肽和聚乙炔手性聚合物（PBLG和L-MSP）组成的双介相样品相结合的分析潜力。这种原始各向异性方法的有效性正在布洛芬等手性分子的对映体分析以及多立体中心手性化合物（(+)-IPC的情况）的构型和3D结构分析的背景下进行探索。

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