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关于微生物群与泌尿生殖系统恶性肿瘤关系的文献计量分析

The bibliometric analysis of documents concerning the relationship between the microbiota and urological malignancies.

作者信息

Bağcı Uygar, Ulusan Bağcı Özlem

机构信息

Department of Pediatric Urology, Ankara Etlik City Hospital, Ankara, Turkey.

Division of Parasitology, Department of Microbiology, Faculty of Medicine, Ankara University, Ankara, Turkey.

出版信息

J Med Microbiol. 2025 Jul;74(7). doi: 10.1099/jmm.0.002041.


DOI:10.1099/jmm.0.002041
PMID:40601380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12222730/
Abstract

The microbiota, which has a major impact on both health and illness, has recently become one of the most popular research topics. To the best of our knowledge, no research has undertaken a bibliometric analysis of publications examining the connection between microbiome and urological cancer to date. In this respect, it is thought that our study will contribute to the literature. The purpose of this study is to raise awareness of the topic by performing a bibliometric analysis of the publications examining the connection between the microbiota and the most common urological cancers, including bladder, prostate, and kidney cancers. All publications about prostate, renal and bladder cancers and microbiota indexed in Web of Science between 2000 and 2024 were included in the study. A total of 310 publications were obtained. Before 2018, there were only three or fewer publications annually; however, following 2018, the number of publications increased rapidly, reaching a peak of 77 in 2024. The USA led with 98 (31.61%) documents, followed by China (60, 19.35%) and Italy (31, 10%). With 19 publications, Hirotsugu Uemura is the most contributing author, followed by Norio Nonomura with 17. Prostate cancer accounted for 45.48% of the publications, bladder cancer for 36.77% and kidney malignancies for 17.64%. Despite the fact that microbiota has been known for 80 years, research on the connection between microbiota and cancer accelerated after the completion of the Human Microbiome Project. The number of studies examining the connection between urological cancer and microbiota peaked in 2024 and is probably going to rise. More research is required on this topic, since the correlation between microbiota and especially prostate and bladder malignancies raises the possibility that variations in microbiota may be utilized in diagnosis, treatment and prognosis.

摘要

微生物群对健康和疾病都有重大影响,最近已成为最热门的研究课题之一。据我们所知,迄今为止,尚无研究对考察微生物组与泌尿系统癌症之间联系的出版物进行文献计量分析。在这方面,我们认为本研究将对文献有所贡献。本研究的目的是通过对考察微生物群与最常见的泌尿系统癌症(包括膀胱癌、前列腺癌和肾癌)之间联系的出版物进行文献计量分析,提高对该主题的认识。本研究纳入了2000年至2024年期间在科学网索引的所有关于前列腺癌、肾癌、膀胱癌和微生物群的出版物。共获得310篇出版物。2018年之前,每年只有三篇或更少的出版物;然而,2018年之后,出版物数量迅速增加,2024年达到77篇的峰值。美国以98篇(31.61%)文献领先,其次是中国(60篇,19.35%)和意大利(31篇,10%)。上村浩次以19篇出版物成为贡献最大的作者,其次是野村纪夫,有17篇。前列腺癌占出版物的45.48%,膀胱癌占36.77%,肾恶性肿瘤占17.64%。尽管微生物群已被知晓80年,但在人类微生物组计划完成后,关于微生物群与癌症之间联系的研究加速。考察泌尿系统癌症与微生物群之间联系的研究数量在2024年达到峰值,并且可能还会增加。由于微生物群与尤其是前列腺癌和膀胱癌之间的相关性增加了微生物群变化可用于诊断、治疗和预后的可能性,因此该主题需要更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/576c0cc79657/jmm-74-02041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/8cf3194a7485/jmm-74-02041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/fcf63f21c78e/jmm-74-02041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/e7114ae95d5f/jmm-74-02041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/576c0cc79657/jmm-74-02041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/8cf3194a7485/jmm-74-02041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/fcf63f21c78e/jmm-74-02041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/e7114ae95d5f/jmm-74-02041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c12/12222730/576c0cc79657/jmm-74-02041-g004.jpg

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本文引用的文献

[1]
The Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers?

Microorganisms. 2025-2-1

[2]
The disease burden of bladder cancer and its attributable risk factors in five Eastern Asian countries, 1990-2019: a population-based comparative study.

BMC Public Health. 2024-9-4

[3]
Microbiome and cancer: from mechanistic implications in disease progression and treatment to development of novel antitumoral strategies.

Front Immunol. 2024

[4]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

[5]
Global epidemiology of kidney cancer.

Nephrol Dial Transplant. 2024-5-31

[6]
Cancer statistics, 2024.

CA Cancer J Clin. 2024

[7]
Causal associations between gut microbiota and urological tumors: a two-sample mendelian randomization study.

BMC Cancer. 2023-9-11

[8]
Next-Generation Sequencing Technology: Current Trends and Advancements.

Biology (Basel). 2023-7-13

[9]
Human gut microbiota in health and disease: Unveiling the relationship.

Front Microbiol. 2022-9-26

[10]
Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers.

Diagnostics (Basel). 2022-7-19

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