Mori Ryota, Taguchi Satoru, Yamamoto Masahiro, Inoue Yuta, Kanazawa Koichiro, Fujii Yoichi, Lee Haesu, Furuse Kiichi, Maki Hiroaki, Kamei Jun, Kakutani Shigenori, Yamada Yuta, Niimi Aya, Yamada Daisuke, Shinozaki-Ushiku Aya, Ushiku Tetsuo, Kurokawa Mineo, Okazaki Mutsumi, Kume Haruki
Department of Urology, Graduate School of Medicine The University of Tokyo Tokyo Japan.
Department of Plastic and Reconstructive Surgery The University of Tokyo Hospital Tokyo Japan.
IJU Case Rep. 2025 May 5;8(4):365-368. doi: 10.1002/iju5.70041. eCollection 2025 Jul.
Drug-induced thrombocytopenia (DITP) can be caused by many kinds of drugs. Its treatment generally involves discontinuation of the responsible drug.
A 70-year-old man received a subcutaneous injection of long-acting (24-week) leuprorelin depot as androgen deprivation therapy for prostate cancer. Four days after the injection, he presented with gingival bleeding and his platelet count was remarkably decreased (< 1000/μL). There was no sign of malignancy but the presence of megakaryocytes on bone-marrow examinations. Considering immune and/or DITP, he started immunoglobulin and steroid therapy while stopping all suspected medications. However, even a month later, his platelet count did not recover with the need for frequent platelet transfusions. Therefore, he eventually underwent surgical resection of the leuprorelin injection site. After the surgery, his platelet count drastically recovered and platelet transfusion became unnecessary.
We report a case of leuprorelin-induced thrombocytopenia that was successfully treated with surgical resection of the injection site.
药物性血小板减少症（DITP）可由多种药物引起。其治疗通常包括停用相关药物。
一名70岁男性接受皮下注射长效（24周）亮丙瑞林缓释剂作为前列腺癌的雄激素剥夺治疗。注射后四天，他出现牙龈出血，血小板计数显著下降（<1000/μL）。骨髓检查未发现恶性肿瘤迹象，但有巨核细胞。考虑到免疫性和/或药物性血小板减少症，他开始接受免疫球蛋白和类固醇治疗，同时停用所有可疑药物。然而，即使一个月后，他的血小板计数仍未恢复，需要频繁输注血小板。因此，他最终接受了亮丙瑞林注射部位的手术切除。手术后，他的血小板计数急剧恢复，不再需要输注血小板。
我们报告一例亮丙瑞林诱导的血小板减少症，通过手术切除注射部位成功治愈。
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