Wong D F, Natarajan T K, Summer W, Tibbits P A, Beck T, Koller D, Kasecamp W, Lamb J, Olynyk J, Philp M S
Am J Cardiol. 1985 Nov 1;56(12):776-80. doi: 10.1016/0002-9149(85)91135-x.
Study of the effects of various diseases and therapeutic manipulation of pulmonary vascular resistance on the right ventricle has been restricted by methodologic limitations. The radioactive gas in solution, krypton-81m was used to study the right ventricle and the technique was compared with a technetium-99m method. In 22 subjects, first-pass krypton-81m right ventricular ejection fraction, acquired both in list mode and electrocardiogram-gated frame mode, correlated well (r = 0.81 and 0.86, respectively, p less than 0.01) with that determined by technetium-99m first-pass studies over a broad range of ventricular function. The reproducibility of the technique was excellent (r = 0.84 and 0.95 for each acquisition mode, respectively). Krypton-81m first-pass studies provide accurate and reproducible estimates of right ventricular function. Use of krypton allows multiple measurements, with or without perturbations, over a short period of time.
各种疾病以及肺血管阻力的治疗性调控对右心室影响的研究一直受到方法学限制。采用溶解于溶液中的放射性气体氪-81m来研究右心室，并将该技术与锝-99m方法进行比较。在22名受试者中，以列表模式和心电图门控帧模式获取的首过氪-81m右心室射血分数，在广泛的心室功能范围内，与锝-99m首过研究测定的结果具有良好的相关性（分别为r = 0.81和0.86，p < 0.01）。该技术的可重复性极佳（每种采集模式的r分别为0.84和0.95）。氪-81m首过研究可提供准确且可重复的右心室功能评估。使用氪可在短时间内进行多次测量，无论有无干扰。
