Pedro Adriana Orcesi, Verdade Roberto Carmignani, Lapa Maura Gonzaga, Brandão Juliana Dinéia Perez, Castilho Vivienne Carduz
Department of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, Brazil.
Libbs Farmacêutica Ltda, Scientific Medical Division, São Paulo, Brazil.
BJOG. 2025 Oct;132(11):1596-1605. doi: 10.1111/1471-0528.18261. Epub 2025 Jul 7.
To estimate the prevalence and symptom severity of premenstrual dysphoric disorder (PMDD) in Brazilian women according to age groups, and to conduct an association analysis between psychoemotional and somatic symptoms.
Cross-sectional study.
303 private clinics across Brazil.
45 160 women aged 20-49 years.
Self-report questionnaire regarding the prevalence and intensity of premenstrual symptoms. Statistical analysis performed using Pearson's chi-square test and Poisson regression and multiple logistic regression.
Prevalence and intensity of somatic and psychoemotional premenstrual symptoms.
Prevalence of PMDD was 3.57% (95% CI: 3.40-3.75). Psychoemotional symptoms were more prevalent than somatic symptoms, with anxiety/tension (99.9%) and irritability/anger (99.8%) being the most frequently reported symptoms. Weight gain (92.5%) and edema (92.1%) were the most prevalent somatic symptoms. Anxiety/tension and headache occurred independently of other symptoms. Binge eating was associated with weight gain (OR = 2.77, 95% CI [2.11, 3.62]), acne (OR = 2.37, 95% CI [1.79, 3.10]), immunoallergic exacerbations (OR = 1.81, 95% CI [1.26, 2;60]) and edema (OR-0.74, 95% CI [0.55, 0.97]). Affective lability was associated with immunoallergic exacerbations (OR = 1.49, 95% CI [1.16, 1.91]) and mastalgia (OR = 1.29, 95% CI [1.02, 1.63]). Depression was associated with acne (OR = 0.72, 95% CI [0.57, 0.89]) and weight gain (OR = 0.77, 95% CI [0.61, 0.96]).
The prevalence of PMDD was consistent with other population studies. Psychoemotional symptoms were more prevalent. Association analysis provided new insights into premenstrual symptomatology.
根据年龄组估算巴西女性经前烦躁障碍（PMDD）的患病率及症状严重程度，并对心理情绪症状与躯体症状进行关联分析。
横断面研究。
巴西全国303家私人诊所。
45160名年龄在20 - 49岁的女性。
采用关于经前症状患病率及严重程度的自填问卷。使用Pearson卡方检验、泊松回归和多重逻辑回归进行统计分析。
经前躯体症状和心理情绪症状的患病率及严重程度。
PMDD的患病率为3.57%（95%CI：3.40 - 3.75）。心理情绪症状比躯体症状更常见，焦虑/紧张（99.9%）和易怒/愤怒（99.8%）是最常报告的症状。体重增加（92.5%）和水肿（92.1%）是最常见的躯体症状。焦虑/紧张和头痛独立于其他症状出现。暴饮暴食与体重增加（OR = 2.77，95%CI [2.11, 3.62]）、痤疮（OR = 2.37，95%CI [1.79, 3.10]）、免疫过敏加重（OR = 1.81，95%CI [1.26, 2.60]）和水肿（OR = 0.74，95%CI [0.55, 0.97]）相关。情感易激惹与免疫过敏加重（OR = 1.49，95%CI [1.16, 1.91]）和乳房胀痛（OR = 1.29，95%CI [1.02, 1.63]）相关。抑郁与痤疮（OR = 0.72，95%CI [0.57, 0.89]）和体重增加（OR = 0.77，95%CI [0.61, 0.96]）相关。
PMDD的患病率与其他人群研究结果一致。心理情绪症状更为普遍。关联分析为经前症状学提供了新的见解。
