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粪便微生物群移植在特定神经退行性疾病和神经发育障碍中的作用。

The role of fecal microbiota transplantation in selected neurodegenerative diseases and neurodevelopmental disorders.

作者信息

Sopel Anna, Szczuciński Wiktor, Gosiewski Tomasz, Salamon Dominika

机构信息

Students' Scientific Group of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.

Microbiome Research Laboratory, Department of Molecular Medical Microbiology, Division of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.

出版信息

Prz Gastroenterol. 2025;20(2):127-141. doi: 10.5114/pg.2024.146118. Epub 2024 Dec 22.

Abstract

Fecal microbiota transplantation (FMT) is a medical procedure that allows to establish a stable and healthy intestinal microbiota in various diseases believed to be related to a gut dysbiosis. Currently, FMT is successfully used to treat recurrent infection. However, in recent years there has been evidence that changes in composition of gut microbiota may also be relevant in the pathogenesis of several neuropsychiatric and neurodevelopmental conditions including Alzheimer's disease, multiple sclerosis, Parkinson's disease, autism spectrum disorders and schizophrenia. This review focuses on exploring the complex connection between gut microbiota and pathogenesis of these neurological conditions. It also presents current research on a possible use of FMT as a therapeutic intervention targeting the gut-brain axis.

摘要

粪便微生物群移植(FMT)是一种医疗程序,可在各种被认为与肠道微生物群失调相关的疾病中建立稳定且健康的肠道微生物群。目前,FMT已成功用于治疗复发性感染。然而,近年来有证据表明,肠道微生物群组成的变化在包括阿尔茨海默病、多发性硬化症、帕金森病、自闭症谱系障碍和精神分裂症在内的几种神经精神和神经发育疾病的发病机制中也可能具有相关性。本综述着重探讨肠道微生物群与这些神经系统疾病发病机制之间的复杂联系。它还介绍了目前关于将FMT作为针对肠-脑轴的治疗干预措施的可能性的研究。

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本文引用的文献

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